We developed an algorithm, Lever, that systematically maps metazoan DNA regulatory motifs or motif combinations to sets of genes. Lever assesses whether the motifs are enriched in cis-regulatory modules (CRMs), predicted by our PhylCRM algorithm, in the noncoding sequences surrounding the genes. Lever analysis allows unbiased inference of functional annotations to regulatory motifs and candidat...

A differential operator D commuting with an S-action is said to be rigid if the non-constant Fourier coefficients of kerD and coker D are the same. Somewhat surprisingly, the study of rigid differential operators turns out to be closely related to the problem of defining Chern numbers on singular varieties. This relationship comes into play when we make use of the rigidity properties of the com...

It is well established that hypoxia causes excess accumulation of glutamate in developing neural tissues. This study aimed to elucidate the mechanism by which glutamate can cause retinal ganglion cell (RGC) death through the N-methyl-D-aspartate (NMDA) receptors (NR) in the developing retina. One-day-old Wistar rats were exposed to hypoxia for 2 hours and then killed at different time points. N...

Exogenous bone morphogenetic proteins (Bmp) are well known to induce ectopic bone formation, but the physiological effect of Bmp signaling on normal bone is not completely understood. By deleting the receptor Bmpr1a in osteoblast lineage cells with Dmp1-Cre, we observed a dramatic increase in trabecular bone mass in postnatal mice, which was due to a marked increase in osteoblast number that wa...

Cynthia Feltner, MD, MPH; Ina F. Wallace, PhD; Christine E. Kistler, MASc; Manny Coker-Schwimmer, Daniel Jonas, MPH

Objective. To evaluate primary care reform (PCR) in Barcelona during the year 2000 using 3 preventive practices: anti-smoking advice, blood pressure measurement, and flu vaccination. Any inequalities of gender, age, or social class in receiving these practices are also assessed. Design. Cross-sectional, descriptive, observational study. Setting. Barcelona Health Survey, primary health care, Spa...

Efficacy of three rates of aldicarb for control of Hoplolaimus columbus was evaluated on highly tolerant ('Foster'), moderately tolerant ('Coker 368'), and highly susceptible ('Braxton') soybean cultivars planted on 28 June 1985. Average yields of the nontreated cultivars were 557 kg/ha for Braxton, 1,309 kg/ha for Coker 368, and 1,682 kg/ha for Foster. Yield differences were significant. Aldic...

The plant defensin NaD1, from Nicotiana alata, has potent antifungal activity against a range of filamentous fungi including the two important cotton pathogens, Fusarium oxysporum f. sp. vasinfectum (Fov) and Verticillium dahliae. Transgenic cotton plants expressing NaD1 were produced and plants from three events were selected for further characterization. Homozygous plants were assessed in gre...