PURPOSE To elucidate the reliability of MRI as a non-invasive tool for assessing in vivo muscle health and pathological amelioration in response to Losartan (Angiotensin II Type 1 receptor blocker) in DyW mice (mouse model for Laminin-deficient Congenital Muscular Dystrophy Type 1A). METHODS Multiparametric MR quantifications along with histological/biochemical analyses were utilized to measu...

LIVER FIBROSIS IS THE COMMON RESPONSE to chronic liver injury and is due to the abnormal accumulation of extracellular matrix (ECM). In response to injury, activated hepatic stellate cells (HSCs) proliferate and produce excess amounts of ECM in response to inflammatory cytokines and growth factors (1, 2, 7). Among these mediators, transforming growth factor(TGF) is the major profibrogenic cytok...

Osteocytes are terminally differentiated osteoblasts which reside in a mineralized extracellular matrix (ECM). The factors that regulate this differentiation process are unknown. We have investigated whether ECM mineralization could promote osteocyte formation. To do this we have utilised MLO-A5 pre-osteocyte-like cells and western blotting and comparative RT-PCR to examine whether the expressi...

Leiomyomas (fibroids) are monoclonal tumors in which myometrial stem cells (MSCs) turn tumorigenic after mutation, abnormal methylation, or aberrant signaling. Several factors contribute to metabolic dysfunction obesity, including cellular proliferation, oxidative stress, and DNA damage. The present study aims determine how adipocytes adipocyte-secreted affect changes MSCs a manner that promote...

Rationale: As the central hallmark of liver fibrosis, transdifferentiation hepatic stellate cells (HSCs), predominant contributor to fibrogenic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aimed characterize roles H3K27 methyltransferase EZH2 demethylase JMJD3 identify their effective pathways novel targ...

Mesoporous bioactive nanoparticles (MBNs) have been developed as promising additives to various types of bone or dentin regenerative material. However, biofunctionality of MBNs as dentin regenerative additive to dental materials have rarely been studied. We investigated the uptake efficiency of MBNs-NH2 with their endocytosis pathway and the role of MBNs-NH2 in odontogenic differentiation to cl...

Abstract Background About half of patients with Crohn’s Disease (CD) require surgery in the course treatment, furthermore, reoperation for later recurrence is also performed high frequency. One characteristic findings CD creeping fat (CF) wrapped around inflamed areas intestine, and CF correlates stenosis intestinal tract resulting from changes connective tissue wall. Lower postoperative recurr...

BACKGROUND The use of platelet rich plasma (PRP, GLO) has been used as an adjunct to various regenerative dental procedures. The aim of the present study was to characterize the influence of PRP on human gingival fibroblasts, periodontal ligament (PDL) cells and osteoblast cell behavior in vitro. METHODS Human gingival fibroblasts, PDL cells and osteoblasts were cultured with conditioned medi...