During the last decade there are new developments in site-specific formulations for targeting drug to the colon. Colon has proved to be a site for the absorption of poorly soluble drugs. Micro carriers as colon drug delivery System has gained importance for the delivery of the drug in the colon because of their increase biocompatibility, controlled release of drug and higher stability. This rev...

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth. However, the anti-cancer role of DZNep in colon cancer cells has been rarely studied. In this st...

Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive...

Colon cancer is the third most common cancer in the world. The overexpression of tissue factor (TF) in colon cancer cells makes it an ideal target for colon cancer therapy. The purpose of the present study was to develop a TF-targeting energized fusion protein, mlFVII-LDP-AE, which is composed of a mouse Factor VII light chain (mlFVII) as the targeting domain conjugated to the highly cytotoxic ...

Inulin is a versatile, water-soluble polysaccharide that commonly available in nature. In the pharmaceutical industry, non-digestible function of inulin has made it attractive. granted with GRAS status by FDA and more than 30,000 plants nature store as carbohydrate. The chicory key plant source out all sources. It can be used sugar or fat replacer processed foods to influence desirable characte...