background: previous studies indicate a high incidence of digestive cancers along southern parts of caspian sea including ma­zandaran province. the present study was conducted to further investigate time to occurrence, age distribution and pos­sible risks associated with the incidence time of digestive cancers in the above regions. methods: for this purpose the data of digestive cancer incidenc...

The Bcl-2 homologue Bak is a potent inducer of apoptosis. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the entire coding region of the bak gene (exons 2-6) in 24 primary gastric cancers (6 early-stage and 18 advanced-stage cancers) and 20 primary colorectal cancers (6 early-stage and 14 advanced-stage cancers). The data herein demonstrate, for the ...

Abstract This Invited Editorial towards the Special Issue on Hepatobiliary and Pancreatic Surgery highlights global problem of young-onset cancers. The paucity data pancreatobiliary cancers is presented in context its relevance to India (and large component adults at-risk age group for these cancers). In face limited information underlying cause cancers, author draws attention evidence from col...

background a considerable portion of gastrointestinal malignancies undergoes surgery without curative resection. this study was conducted to assess surgical outcome in patients with gastrointestinal cancers. methods we reviewed individuals with esophagus, stomach, colon and rectum cancers admitted for surgical treatment after initial preoperative evaluations. surgical outcome, stage of tumors a...

Background: Colorectal cancer is the third most common type of aggressive cancers. Chemotherapy, surgery,and radiotherapy are the common therapeutic options for treating this cancer. Due to the adverse side-eff ects of these methods, immunotherapy is considered as an appropriate alternative therapeutic option. Treatment through the application of monoclonal antibodies is considered as a n...

INTRODUCTION Hypermethylation of the promoter region of the hMLH1 gene is associated with absent expression of MLH1 protein in sporadic colorectal cancers with microsatellite instability (MSI+), and it has been proposed that methylation may be a mechanism of inactivation in Knudson's hypothesis. The incidence of hypermethylation of the hMLH1 promoter in hereditary non-polyposis colorectal cance...

PURPOSE MicroRNAs (miRNA) have potential prognostic value for colorectal cancers; however, their value based on patient race/ethnicity and pathologic stage has not been determined. The goal was to ascertain the prognostic value of 5 miRNAs with increased expression in colorectal cancers of African American (black) and non-Hispanic Caucasian (white) patients. EXPERIMENTAL DESIGN TaqMan quantit...

background: cancer is the second most common cause of non-accidental death in iran. geographical, racial and habitual differences have led to the variation in the incidence of cancer in different regions of this country. this study was performed to determine the incidence of cancer in the kerman province, central iran. methods: all newly diagnosed cases of cancer in the kerman province were rec...

Purpose: MicroRNAs (miRNA) have potential prognostic value for colorectal cancers; however, their value based on patient race/ethnicity and pathologic stage has not been determined. The goal was to ascertain the prognostic value of 5 miRNAs with increased expression in colorectal cancers of African American (black) and non-Hispanic Caucasian (white) patients. Experimental Design: TaqMan quantit...

although there is evidence that vitamin d deficiency leads to the development of several cancers, including colorectal cancer, research has shown gaps in establishing a relationship between hypovitaminosis d and the incidence of colorectal cancer. there are controversial reports and inadequate scientific evidence about the role of age and race-specific dosage of vitamin d supplementation for ch...