A Thai woman, with no family history of bleeding disorders, presented with excessive bleeding after minor trauma and tooth extraction. The screening coagulogram revealed prolonged activated partial thromboplastin time and prothrombin time. The specific-factor assay confirmed the diagnosis of combined factor V and factor VIII deficiency (F5F8D). Her plasma levels of factor V and factor VIII were...

Protein-C inhibitor (PCI) is a newly described plasma inhibitor directed against a vitamin-K-dependent serine protease, activated protein-C, which is involved in the inactivation of factor V and factor VIII. Marlar and Griffin have reported that PCI activity is absent in the plasma of patients with congenital combined factor V/VIII deficiency. We have measured the levels of PCI in the plasma of...

Combined factor V and VIII deficiency is a rare autosomal recessive disorder with incidence of one in 10,00,000. We reported case seventy-one-year-old patient third degree uterovaginal prolapse, diagnosed as combined the successful perioperative management during vaginal hysterectomy. With our experience this, we conclude that for patient's correction should be given at least 2 weeks post opera...

The classification of factor VIII deficiency, generally used based on plasma levels of factor VIII, consists of severe (<1% normal factor VIII activity), moderate (1% to 4% factor VIII activity), or mild (5% to 25% factor VIII activity). A recent communication described four individuals bearing identical factor VIII mutations. This resulted in a severe bleeding disorder in two patients who carr...

Correspondence: Başak Ünver Koluman, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Hematoloji Kliniği, Ankara, Türkiye Email: [email protected] Received: 02.12.2013, Accepted: 04.03.2014 Copyright © JCEI / Journal of Clinical and Experimental Investigations 2014, All rights reserved JCEI / 2014; 5 (2): 323-325 Journal of Clinical and Experimental Investigations doi: 10.5799/ahinjs....