A NADES, choline chloride/water, allows a high yielding preparation of pure quinoxalines embedding acid sensitive and other functional groups at room temperature in very short reaction time.

We examined the effects of exogenous choline (30, 60, 120 mg/kg, i.p.) on basal and scopolamine-evoked acetylcholine (ACh) release in awake animals, using in vivo microdialysis. After collection of 3-4 baseline dialysate samples (15 min each), rats received either saline or choline chloride and 4 additional samples were collected. All animals then received scopolamine hydrochloride (0.5 mg/kg, ...

Approximately half of the world’s pineapple production is marketed as a processed product, leading to generation significant quantity industrial waste, mainly composed peels, cores, and crowns. This study evaluated deep eutectic solvents (DESs) for assisted microwave extraction phenolic compounds from peels their antioxidant capacity. DESs are considered environmentally friendly characterized b...

Cobalt and manganese were selectively leached from LiNMC using an oxalic acid : choline chloride deep eutectic solvent, resulting in a nickel-enriched solid residue.

In this article a strategy is proposed for the design of low toxic, room temperature liquid low-melting mixtures (LMMs) which are entirely composed of natural materials. From literature it is well known that, in general, deep eutectic solvents based on choline chloride and dicarboxylic acids are LMMs, but not liquids at room temperature, with one exception: a 1 : 1 molar mixture of malonic acid...

The ionothermal synthesis of Ca-MOFs has been performed using the 1 : 2 choline chloride e-urea deep eutectic solvent, allowing preparation water sensitive materials.

This study investigated whether dietary choline can prevent endotoxin shock. Female Sprague-Dawley rats fed chow or chow plus choline chloride (0.025-0.4%) for 3 days were given lipopolysaccharide (LPS) via the tail vein. Eighty-three percent and 56% of chow-fed rats survived after 2.5 or 5.0 mg/kg LPS, respectively. Choline increased survival in a dose-dependent manner, with maximal effects ob...