An in-depth analysis of Dorian Shainin’s variable search (VS) method is carried out. Conditions under which the VS approach does and does not work well in comparison to traditional designs are identified. Explicit expressions for the expected number of runs and the probability of correct screening are derived under stated assumptions. The crucial roles of process knowledge and noise variation i...

Instrumental-variable (IV) methods were invented over 70 years ago, but remain uncommon in epidemiology. Over the past decade or so, non-parametric versions of IV methods have appeared that connect IV methods to causal and measurement-error models important in epidemiological applications. This paper provides an introduction to those developments, illustrated by an application of IV methods to ...

The preparation of multipartite entangled states is the prerequisite for exploring quantum information networks and quantum computation. In this Letter, we present what we believe is the first experimental demonstration of an eight-partite spatially separated continuous variable (CV) cluster state of optical modes. Via the linearly optical transformation of eight squeezed states of light, the e...

Econometric analyses of treatment response often use instrumental variable (IV) assumptions to identify treatment effects. The traditional IV assumption holds that mean response is constant across the subpopulations of persons with different values of an observed covariate. Manski and Pepper (2000) introduced monotone instrumental variable (MIV) assumptions, which replace equalities with weak i...

The permutation flow shop scheduling problem (PFSSP) is part of production scheduling, which belongs to the hardest combinatorial optimization problem. In this paper, a multipopulation particle swarm optimization (PSO) based memetic algorithm (MPSOMA) is proposed in this paper. In the proposed algorithm, the whole particle swarm population is divided into three subpopulations in which each part...

We explored the theoretical underpinnings of a commonly used training strategy by examining issues of training and transfer of skill in the context of a complex video game (Space Fortress, Donchin, 1989). Participants trained using one of two training regimens: Full Emphasis Training (FET) or Variable Priority Training (VPT). Transfer of training was assessed with a large battery of cognitive a...

This paper reports evidence that an individual meeting with a study counselor at high school significantly improves the quality of choice of tertiary educational field, as self-assessed 18 months after graduation from college. To address endogeneity, we explore the variation in study counseling practices between schools as an instrumental variable (IV). Following careful scrutiny of the validit...

The use of instrumental variable (IV) methods is attractive because, even in the presence of unmeasured confounding, such methods may consistently estimate the average causal effect of an exposure on an outcome. However, for this consistent estimation to be achieved, several strong conditions must hold. We review the definition of an instrumental variable, describe the conditions required to ob...

Variable angle spinning (VAS) experiments provide a useful method for measuring long-range dipolar couplings and obtaining isotropic-anisotropic correlation spectra. These experiments make it possible to obtain correlations between isotropic and anisotropic spectra without altering the chemical composition of the sample. They also allow working with very strongly oriented systems that are not a...