background: in most mammals, sex is determined at the beginning of gestation by the constitution of the sex chromosomes, xy in males and xx in females. case: here we report an interesting case characterized by ambiguous genitalia and ovotestis in a newborn carrying an apparently female karyotype (46 xx). array comparative genomic hybridization (array-cgh) revealed an unbalanced rearrangement re...

BACKGROUND The ratio of two measured fluorescence signals (called x and y) is used in different applications in fluorescence microscopy. Multiple instances of both signals can be combined in different ways to construct different ratio estimators. METHODS The mean and variance of three estimators for the ratio between two random variables, x and y, are discussed. Given n samples of x and y, we...

The statistical analysis of array comparative genomic hybridization (CGH) data has now shifted to the joint assessment of copy number variations at the cohort level. Considering multiple profiles gives the opportunity to correct for systematic biases observed on single profiles, such as probe GC content or the so-called "wave effect." In this article, we extend the segmentation model developed ...

................................................................................................................................ 9 INTRODUCTION ..................................................................................................................... 10 REVIEW OF THE LITERATURE ......................................................................................... 11 1. Cancer and ...

We consider separating signal and noise in data measuring genetic abnormalities of cancer tumor cells. The linked hot-cold model is introduced and t to data from a comparative genomic hybridization study of bladder cancer. We analyze these data and report details of the calculation summarized in Yeager et al. 1998. The model-generating framework developed in Newton et al. 1998 is used to motiva...