11 In rule-based modeling, molecular interactions are systematically specified in the form of reaction rules 12 that serve as generators of reactions. This provides a way to account for all the potential molecular 13 complexes and interactions among multivalent or multistate molecules. Recently, we introduced rule14 based modeling into the Virtual Cell (VCell) modeling framework, permitting gra...

Abstract There are two types of models useful in the study of worm propagation for a given number of terminals in a trusted network i.e. deterministic and stochastic model. The deterministic models, also known as compartmental models are in the form of epidemic models. These epidemic models consist of different states called compartments so these models are also known as compartmental models. A...

Are single neocortical neurons as powerful as multi-layered networks? A recent compartmental modeling study has shown that voltage-dependent membrane nonlinearities present in a complex dendritic tree can provide a virtual layer of local nonlinear processing elements between synaptic inputs and the final output at the cell body, analogous to a hidden layer in a multi-layer network. In this pape...

Electrical brain stimulation (EBS) is an appealing method to treat neurological disorders. To achieve optimal stimulation effects and a better understanding of the underlying brain mechanisms, neuroscientists have proposed computational modeling studies for a decade. Recently, multi-scale models that combine a volume conductor head model and multi-compartmental models of cortical neurons have b...

Techniques of in vitro whole-cell recording and compartmental modeling were combined to investigate dendritic structure and calcium currents in individual thalamocortical neurons. Voltage-clamp recordings of IT obtained in intact and dissociated ventrobasal neurons were used to constrain IT conductances and passive parameters incorporated in morphorealistic models. High dendritic IT densities w...

There are rats in the basement. When they scurry around, they knock the fuse box and short out the power supply. Consequently, only if the rats are absent today does icking the light switch turn on the lights. This article discusses the use of a simple and-or graph representation to handle such abler statements in qualitative compartmental modeling framework. Abstract There are rats in the base...