نتایج جستجو برای: composite microparticle

تعداد نتایج: 123812  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Dylan Burger Augusto C Montezano Nobuhiro Nishigaki Ying He Anthony Carter Rhian M Touyz

OBJECTIVE Circulating microparticles are increased in cardiovascular disease and may themselves promote oxidative stress and inflammation. Molecular mechanisms underlying their formation and signaling are unclear. We investigated the role of reactive oxygen species (ROS), Rho kinase, and lipid rafts in microparticle formation and examined their functional significance in endothelial cells (ECs)...

Journal: :Journal of lipid research 2009
Shilpi Nandi Loretta Ma Maxime Denis Joel Karwatsky Zhiqiang Li Xian-Cheng Jiang Xiaohui Zha

ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-poor apolipoprotein A-I (apoA-I) and generates HDL. Here, we demonstrate that ABCA1 also directly mediates the production of apoA-I free microparticles. In baby hamster kidney (BHK) cells and RAW macrophages, ABCA1 expression led to lipid efflux in the absence of apoA-I and released large microparticles devoid of a...

2013
Anne Clémence Vion Anna A. Birukova Chantal M. Boulanger Konstantin G. Birukov

Microparticle release by vascular endothelium has been implicated in various cardiovascular pathologies. Ventilator-induced lung injury (VILI) is a life-threatening complication of mechanical ventilation at high tidal volumes associated with excessive mechanical stretch of pulmonary vascular endothelial cells. However, a role of VILI-relevant levels of cyclic stretch in microparticle generation...

2013
J. A. NAIRN

The “multimaterial” version of the material point method (MPM) extrapolates each material to its own velocity field on a background grid. By reconciling momenta on nodes interacting with two or more materials, MPM is able to automatically handle contact without any need for special contact elements. This paper extends multimaterial MPM to automatically handle imperfect interfaces between materi...

2017
Qigui Li Lisa Xie Diana Caridha Qiang Zeng Jing Zhang Norma Roncal Ping Zhang Chau Vuong Brittney Potter Jason Sousa Sean Marcsisin Lisa Read Mark Hickman

Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate doses for 2, 4, 6, or 8 weeks prior to infection with P. berghei sporozoites. The liver stage effi...

Journal: :Cardiovascular research 2003
Marja J VanWijk E VanBavel A Sturk R Nieuwland

Microparticles are membrane vesicles released from many different cell types. There are two mechanisms that can result in their formation, cell activation and apoptosis. In these two mechanisms, different pathways are involved in microparticle generation. Microparticle generation seems to be a well regulated process. Microparticles vary in size, phospholipid and protein composition. They have a...

Journal: :Radiation protection dosimetry 2011
J S Eakins J Th M Jansen R J Tanner

Uranium microparticles (radii: 50 nm-1.25 μm) were modelled surrounded by tissue and exposed to natural background radiation, in order to investigate potential dose enhancements from photon interactions. Generally, the results depended on the microparticle size. For a 0.5 μm radius microparticle in an isotropic field, it was found that the combined photon/electron doses deposited in 1 and 10 μm...

Hadi Valizadeh, Jaleh Barar Mitra Jelvehgari, Nasrin Heidari

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...

Journal: :Revista espanola de cardiologia 2015
Silvia Montoro-García Eduard Shantsila Benjamin J Wrigley Luke D Tapp José Abellán Alemán Gregory Y H Lip

INTRODUCTION AND OBJECTIVES Microparticles are markers for cell activation and apoptosis and could provide valuable information that is not available from clinical data. This study assesses the clinical and biological relationship of small-sized microparticles in different forms of ischemic systolic heart failure and their relation to markers of inflammation and repair. METHODS We compared 49...

2016
Andraž Rešetič Jerneja Milavec Blaž Zupančič Valentina Domenici Boštjan Zalar

The need for mechanical manipulation during the curing of conventional liquid crystal elastomers diminishes their applicability in the field of shape-programmable soft materials and future applications in additive manufacturing. Here we report on polymer-dispersed liquid crystal elastomers, novel composite materials that eliminate this difficulty. Their thermal shape memory anisotropy is imprin...

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