Background: Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. Methods: In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors (6-hydroxy-4-methylquinolin-2(1H)-one derivatives) using the spontan...

background: magnetite (fe3o4) nanoparticles are currently one of the important and acceptable magnetic nanoparticles for biomedical applications. to use magnetite nanoparticles for bacteria cell separation, the surface of nanoparticles would be modified for immobilizing of nanoparticles on the surface of bacteria. functionalization of magnetite nanoparticles is performed by different surfactant...

the effects of adenosine,5-n-ethylcarbox-amidoadenosine (neca), 2-chloroadenosine (2-ca), n6-phenyiisopropyladenos'tne (l-pia and d-pia) and n6 -cyclohexyladenos'tne (cha) were examined on the mouse isolated vas deferens. all the compounds in a concentration-dependent manner inhibited electrically induced contrac¬tions. ic of adenosine and its analogues were 13.68 ± 5.97 for ado, 0.736 ± 0.087 ...

a lithium borate thermoluminescence dosimeter with 0.3 wt% of manganese impurityconcentration was prepared for high dose levels in the range of 1-30 kgy for gamma irradiation applications.the tld reader was used for read out purposes from ambient temperature to about 400°c with a heating rate of 6°c/sec. the pre- and post- irradiation anneal temperature was 300°c for 1.5 and 1 hours respectivel...

premature chromosome condensation (pcc) appears to have a possible utility for biological dosimetry purposes. the pcc technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. for this purpose, human blood samples were exposed in vitro to 60co up to 10 gy and the pcc technique was performed immediately after irradiation. anal...

BACKGROUND Previous study has shown that fentanyl attenuates acetylcholine-induced vasorelaxation. The goal of the current in vitro study was to identify the muscarinic receptor subtype that is mainly involved in the fentanyl-induced attenuation of endothelium-dependent relaxation elicited by acetylcholine. METHODS The effects of fentanyl and muscarinic receptor antagonists on the acetylcholi...

We investigated the responsiveness of the mouse basilar artery to acetylcholine (ACh), bradykinin (BK), noradrenaline (NA), 5-hydroxytryptamine (5-HT), histamine (His) and angiotensin (Ang) II in order to characterize the related receptor subtypes in vitro. ACh and BK induced endothelium-dependent relaxation of precontracted arteries with U-46619 (a thromboxane A2 analogue). Atropine (a non-sel...

conclusion the results of the study suggest that biofeedback training may help to train stressed athletes to acquire a control over their psychophysiological processes, thus helping an athlete to perform maximally. results two way repeated measure anova was used to simultaneously compare within and between group differences. response time, concentration, heart rate variability, respiration rate...