introduction: activation of n-methyl-d-aspartate (nmda) glutamate receptors in the nucleus accumbens is a component of drug-induced reward mechanism. in addition, nmda receptors play a major role in brain reward system and activation of these receptors can change firing pattern of dopamine neurons. blockade of glutamatergic neurotransmission reduces the expression of conditioned place preferenc...

downward phase of dose-response morphine converted u shape curve was chosen as a base for investigating the effects of different doses of naloxone (0.05-0.4 mg/kg) on morphine reward/aversion properties using place preference method. first, male wistar rats (200-220 g) were received morphine (1-7.5 mg/kg) for place conditioning and marginal dose of morphine (5 mg/kg) calculated by graphpad soft...

background: dendritic cells (dc) induce tumor or pathogen-specific t cell responses in humans. several laboratories have developed culture systems, including maturation factors for human dc from peripheral blood monocytes. we comprehensively compared standard maturation stimulus, an autologous monocyte-conditioned medium (mcm), with heparin for their ability to promote uniformly mature dc that ...

divine essence and explanation of his ontological place is an important problem for religious schools in conceptual and direct knowledge and both the philosophers and mystics concerns about it. mystics believed the method of intuition, but afterwards the emergence of speculative mysticism, they try to translate the intellectual intuition to conceptual knowledge, attaining this purpose, they use...

increasing the concentration of ammonia in water can cause fish death. this study was conducted to compare the performance of conditioned activated carbon and zeolite in ammonia (tan = total ammonia nitrogen) removal in a simulated transport of rainbow trout fry in 40-liter plastic bags. hence, responses of zeolite and conditioned activated carbon in ammonia (tan) removal at different concentra...