Background & Aims: Thyroid hormones are of great importance in the development of the central nervous system. Congenital hypothyroidism may affect the reorganization of specific and non-specific thalamocortical afferents to whisker–related sensory (wS1) corticol region in rats. Methods: Congenital hypothyroidism was induced by adding propylthiouracil (PTU) (25 ppm) to the rats...

OBJECTIVE The aim of this study was to investigate depression-like behaviors of juvenile rats with congenital and postnatal hypothyroidism. METHODS Twenty-seven newborn rat pups were used. First, 6-month-old Wistar Albino female rats were impregnated. Methimazole (0.025% wt/vol) was given to dam rats from the first day of pregnancy until postnatal 21 days (P21) to generate pups with congenita...

Introduction: Congenital hypothyroidism is the most common cause of mental retardation in the world. The presence of hypothyroidism in fetal is lead to abnormalities in major organs, including nervous system and central skeleton. Aim of this study was to investigate epidemiologic situation of neonatal hypothyroidism in Ilam province between 2005 -2011. Materials and methods: This was a cross-s...

Dear Editor-in-Chief: I read and enjoyed your stylish article, "Frequency of Congenital Cardiac Malformations in Neonates with Congenital Hypothyroidism", in relation to heart disease with hypothyroidism. As we know, one of the most commonly associated congenital hypothyroidism disorders is congenital heart disease, which has a significant effect on the recovery of pat...

AIM Primary congenital hypothyroidism is frequently seen endocrine disorder and one of the preventable cause of mental retardation. Aim of study was to evaluate the frequency of permanent/transient hypothyrodism, and to detect underlying reason to identfy any marker which carries potential to discriminate permanent/transient form. MATERIAL AND METHODS Forty eight cases older than 3 years of a...

Although hypothyroidism is a common cause of menorrhagia, it is an uncommon presentation of congenital hypothyroidism. We report a case of congenital hypothyroidism presenting in adulthood with severe menorrhagia. Despite the late presentation, she had features to suggest hypothyroidism since birth.

introduction: congenital hypothyroidism is one of the most preventable causes of mental retardation. worldwide, incidences vary from 1:3000 to 1:4000 and mean incidence in iran is estimated to be 1:1000. neonatal screening and early treatment within first 2 weeks of neonatal period can prevent neurocognitive deficits. we aimed to study the incidence of ch and increased levels of tsh in yazd pro...