A randomized, double-masked, crossover clinical trial was carried out to evaluate whether lovastatin therapy (60 mg daily) affects the initiation of oxidation of low density lipoprotein (LDL) in cardiac patients on alpha-tocopherol supplementation therapy (450 IU daily). Twenty-eight men with verified coronary heart disease and hypercholesterolemia received alpha-tocopherol with lovastatin or w...

The five-membered zirconacycloallenoids 2 react rapidly with dihydrogen under mild conditions to yield the corresponding (s-cis-conjugated diene)zirconocenes 3. The reaction involves splitting of the H(2) molecule between the metal center and a ligand carbon atom.

The purpose of the present study was follow the influence of periodical storage (at room temperature, 25-30°C), on the stability of oil including primary and secondary oxidation, total oxidation as well as conjugation. Color intensity at 430 nm of the oil samples was also evaluated to show changes of color during periodical storage. It was generally found peroxide value, panisidine, total oxida...

The present work has been undertaken to study the effect of ambrex, a polyherbal formulation on experimental gastric ulceration and their possible antioxidative mechanism to cure ulcer. Gastric mucosal damage was produced in rats by administering 200 mg/kg orally. Aspirin was found to cause severe haemorrhagic lesions mainly through oxidative damage of the mucosa as indicated by increased lipid...

The antioxidant and anticandidal activities of leaves obtained from Camellia sinensis by non-fermentation (green and white teas), semi-fermentation (red tea) and fermentation method (black tea) were investigated. It was evaluated the total phenolic content by Folin-Ciocalteau assay; antioxidant capacities were evaluated in vitro using DPPH and ABTS radicals, hypochlorous acid and superoxide ani...

The surface functionalization of conjugated polymers such as the poly(alkoxythiophenes) poly(3,4ethylenedioxythiophene) (PEDOT) and poly(3,4-propylenedioxythiophene) (PProDOT) provides a potential means for systematically tailoring their physical properties. We previously reported the synthesis of an alkene-functionalized 3,4-propylenedioxy-thiophene (ProDOT) derivative that could be readily mo...

The pathobiochemical mechanism of arteriosclerosis in hyperhomocysteinaemia has not yet been elucidated. In vitro studies have shown that the cytotoxic properties of homocysteine can be ascribed to its generation of reactive oxygen species. We studied lipid peroxidation, both in vivo and in vitro, in 10 homozygous cystathionine synthase-deficient (CSD) patients and in a control group of 10 heal...

background: autoxidation is considered to be the main route of edible oil deterioration, which produces undesirable odors and flavors during storage and heating. the unpleasant flavor of oxidized oil has been attributed to primary and secondary products of unsaturated fatty acids. the microwave heating is a rapid method when compared with other methods of heating. objective: in this research, t...

Acenes such as pentacene have been widely studied over the last decade because of their highly promising potential as organic semiconductors, and have found use in devices such as photovoltaics and field-effect transistors. Nonetheless, the locked s-cis diene units within acenes are an Achilles' heal, in that many acenes readily dimerize and react with oxygen. As a possible alternative, we have...