Ocular melanoma (OM) is a rare noncutaneous malignancy and consists of 2 different subtypes based on the anatomic location in eye: uveal conjunctival melanoma. Like cutaneous melanoma, OM benefits from nuclear medicine molecular imaging nodal staging clinical management. Through illustration distinctive cases, we aim to demonstrate complementary roles standard lymphoscintigraphy, advanced SPECT...

PURPOSE Conjunctival melanoma (CM) is a rare but lethal form of cancer. Similar to cutaneous melanoma, CM frequently carries activating mutations in BRAF and NRAS. We studied whether CM as well as conjunctival benign and premalignant melanocytic lesions express targets in the mitogen-activated protein kinase (MAPK) and AKT pathways, and whether specific inhibitors can suppress CM growth in vitr...

OBJECTIVE To provide clinical details and long-term outcome data for a series of patients with eyelid or conjunctival melanoma or eyelid sebaceous cell carcinoma who underwent sentinel lymph node (SLN) biopsy. DESIGN Retrospective interventional case series with review of clinical records and pathologic specimens. SETTING Tertiary comprehensive cancer center. PATIENTS Twenty-five consecut...

1. Seregard S. Conjunctival melanoma. Surv Ophthalmol. 1998;42:321-350. 2. McDonnell JM, Carpenter JD, Jacobs P, Wan WL, Gilmore JE. Conjunctival melanocytic lesions in children. Ophthalmology. 1989;96: 986-993. 3. Croxatto JO, Iribarren G. Malignant melanoma of the conjunctiva: report of a case. Ophthalmology. 1987;94:1281-1285. 4. Shields CL, Fassiuden A, Mashayekhi A, Shields JA. Conjunctiva...

and similar software but a long sequence of consecutive tests is required.12 It might therefore be more effective if a less sensitive test was used in the first place. With the appearance of FASTPAC and other simple test programs it seems that computerised field analysis is approaching the performance of machines such as the venerable Friedmann visual field analyser. Is the emperor's new suit b...

Tests of cell mediated immunity (one and two stage leucocyte migration inhibition assays) and humoural immunity (membrane immunofluorescence and serum effects on leucocyte migration) were done with leucocytes and sera from 36 patients with uveal melanoma, five with conjunctival melanoma, 21 with non-malignant ocular disease, and 189 with cutaneous melanoma. Cell mediated reactivity with melanom...

Cellular blue nevus is an uncommon pigmented tumor in the conjunctiva, where it generally appears as a deep, circumscribed, pigmented conjunctival mass. We report a case of conjunctival blue nevus that clinically resembled primary acquired melanosis and gave rise to conjunctival melanoma. A 41-year-old man developed a diffuse pigmented mass in the inferior fornix of his left eye. Over a 20-year...

Clinical and histopathological features of four cases of multifocal amelanotic malignant melanoma of the conjunctiva in association with 'acquired melanosis sine pigmento' are reported. The absence ofconjunctival pigmentation in this extremely rare combination of lesions prevented early diagnosis and clinical monitoring. As a result orbital exenteration was required in three cases. This multice...