Irritable bowel syndrome with constipation and chronic functional constipation are common digestive disorders that negatively impact quality of life and account for billions of dollars in health care costs. Related to the heterogeneity of pathogenesis that underlie these disorders and the failure of symptoms to reliably predict underlying pathophysiology, traditional therapies provide relief to...

Chronic constipation is a common disorder in the general population, with higher prevalence in the elderly, and is associated with worse quality of life and with greater health care utilization. Lubiprostone is an intestinal type-2 chloride channel activator that increases intestinal fluid secretion, small intestinal transit, and stool passage. Lubiprostone is currently approved by the US Food ...

BACKGROUND/AIM Functional constipation (FC) and constipation-predominant IBS (C-IBS) are two main subtypes of constipation. Using radio-opaque markers is an easy and cost effective method to measure colonic transit time (CTT). We designed this study to compare the CTT between these two groups of constipated patients. METHODS Patients with chronic constipation of no organic etiology were class...

Table 1. Symptom – Based Treatment of Irritable Bowel Syndrome Pain Predominant Diarrhea Predominant Constipation Predominant Antispasmodic Agents  Dicycloverine (Bentyl)  Mebeverine Tricyclic Antidepressants  Amitriptyline Antidiarrheal Agents  Loperamide (Imodium)  Cholestyramine (questran) Serotonin (5-HT3) antagonist  Alosetron (Lotronex)  Ondansetron (Zofran) Serotonin (5-HT4) Agoni...

BACKGROUND To investigate non-patient irritable bowel syndrome (IBS) change to IBS and to determine factors predictive of the onset of IBS, individual biological factors, psychological factors, behavioral factors, and environmental factors were examined. METHODS The subjects were 105 non-patient IBS (male = 59, female = 46, average age:21.49 +/- 2.37), including 68 of the diarrhea-predominant...

Irritable bowel syndrome (IBS) is considered to be a physical disorder that mainly affects the bowel and is clinically characterized by lower abdominal pain or discomfort, diarrhea, constipation (or alternating diarrhea/constipation), gas, bloating, and nausea. According to recent studies, it appears that there is an association with increased prolactin levels in patients suffering from IBS. We...

Background/Aims The Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C. Methods The voxel-wise analysi...