searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggesstions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Hi...

searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggesstions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Hi...

Array-based Discovery of Aptamer Pairs Report Title Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the sensitivity and specificity of molecular detection. Importantly, such pairs can be conjugated to generate reagents that achieve twosite “bidentate” target recognition, with affinities greatly exceeding either monovalent component. DNA aptamers a...

The continuation paradigm is often used to investigate the behavioral and neural mechanisms of timing. Typically, a movement rate is established by pacing with a metronome. Then, the metronome is turned off and the subject continues at the established rate. Performance during continuation is assumed to be based on internal timing mechanisms. Here, we investigated the degree to which the neural ...

OBJECTIVE The authors examined the rate of response to the combination of nortriptyline and interpersonal psychotherapy for acute and continuation treatment of elderly patients with recurrent major depression. METHOD The subjects were 73 elderly patients, 61 of whom completed treatment. Nortriptyline steady-state blood levels were maintained at 80-120 ng/ml, and interpersonal psychotherapy wa...

Three-dimensional (3D) limit analysis of stability of slopes is presented. Such analyses are not common because of the difficulties in constructing three-dimensional mechanisms of failure in frictional soils. While examples of 3D translational failure patterns are known, no admissible rotational mechanisms for frictional soils have been described in the literature. A class of admissible rotatio...

Previous studies demonstrated that brain signals encode information about specific features of simple auditory stimuli or of general aspects of natural auditory stimuli. How brain signals represent the time course of specific features in natural auditory stimuli is not well understood. In this study, we show in eight human subjects that signals recorded from the surface of the brain (electrocor...

Ferromagnetic resonance (FMR) spectroscopy, x-ray magnetic circular dichroism (XMCD) spectroscopy and magnetic transmission soft x-ray microscopy (MTXM) experiments have been performed to gain insight into the magnetic anisotropy and domain structure of ultrathin Co9Ni multilayer films with a thin permalloy layer underneath. MTXM images with a spatial resolution better than 25 nm were obtained ...

OBJECTIVE To evaluate efficacy, adverse effects, and user continuation rate of an etonogestrel subdermal single-rod contraceptive implant. METHODS A total of 417 healthy volunteers of childbearing age were included in this multicenter trial. After implant insertion, the women were followed up during the 3 years of contraceptive action. At each visit, clinical findings, side effects, and bleed...

1Department of Public Health; 2Department of Epidemiology and Biostatistics, Faculty of Health, Zahedan Medical Sciences University, Zahedan, Islamic Republic of Iran. Received: 08/12/02; accepted: 13/05/03 ABSTRACT We evaluated contraception continuation rates and discontinuation reasons in Zahedan among 1741 women from 1998–2000. By Kaplan–Meier technique continuation rates were 92% for low d...