"Change in Myocardial Contractility Response to Treatment with Norepinephrine Septic Shock." American Journal of Respiratory and Critical Care Medicine, 204(3), pp. 365–368

a 47 year-old female died after mitral valve replacement. post-cardiopulmonary bypass right ventricle was not able to pump despite good left ventricular contractility. at microscopic examination, diffuse right ventricular fatty infiltration was found. we found no previous report of this pathology in patients with mitral stenosis

Dermal fibroblasts play a key role in maintaining homoeostasis and functionality of the skin. Their contractility plays changes observed during ageing, especially processes such as wound healing, inflammation, wrinkling scar tissue formation well structural on extracellular matrix. Although alternations skin physiology morphology have been previously described, there remains paucity information...

background and objective: epidural analgesia (ea) has been used to relieve labor pain in many obstetric units, yet controversy persists about its effect on progress and outcome in labor. the purpose of the current study was to evaluate the effect of ea on the rate of cervical dilation and myometrial contractility. methods: in a 6-month period, 36 women who received standardized ea were matched ...

Abstract Anti-reflux surgery in the setting of preoperative esophageal dysmotility is contentious due to fear persistent long-term dysphagia, particularly individuals with an aperistaltic esophagus (absent contractility). Emerging evidence suggests fundoplication safe and effective patients dysmotility. This study aimed determine postoperative outcomes following absent contractility versus norm...

Elevated expression and activity of matrix metalloproteinase-9 (MMP9) and decreased contractility of cardiomyocytes are documented in diabetic hearts. However, it is unclear whether MMP is involved in the regulation of contractility of cardiomyocytes in diabetic hearts. In the present study, we tested the hypothesis that MMP9 regulates contractility of cardiomyocytes in diabetic hearts, and abl...

BACKGROUND Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not fully elucidated. Our aim was to utilise a human myometrial contractility model to investigate the effect of a number of uterine specific contractility agents in this system. T...

Deregulation in uterine contractility can cause common pathological disorders of the female reproductive system, including preterm labor, infertility, inappropriate implantation, and irregular menstrual cycle. A better understanding of human myometrium contractility is essential to designing and testing interventions for these important clinical problems. Robust studies on the physiology of hum...

BACKGROUND Myocardial contractility can be altered using voltage clamp techniques by modulating amplitude and duration of the action potential resulting in enhanced calcium entry in the cell of isolated muscle strips (Non-Excitatory Currents; NEC). Extracellular electrical stimuli delivered during the absolute refractory period (Cardiac Contractility Modulation; CCM) have recently been shown to...