Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered fr...

Corneal biopsy specimens from 3 patients with Cogan's microcystic corneal dystrophy were examined by light and electron microscopy. Specimens were taken from corneas showing microcysts, geographic or map-like areas, and refractile striae. In all samples there is a bilaminate subepithelial layer of fibrogranular material, the friability of which is probably the basis for recurrent erosions in th...

In 1988 six men were referred to St Paul's Eye Hospital after the onset of acutely painful, red eyes while at work at a local sausage casing factory. These patients prepared sheep intestine for sausage skin manufacture. Ocular examination showed bilateral blepharospasm, photophobia and lacrimation, intense conjunctival injection, and superficial punctate corneal erosions. There were no other ab...

PURPOSE To report the diagnosis and management of a patient with chronic ophthalmic topical anesthetic abuse and floppy eyelid syndrome. METHODS We describe the case of a 47-year-old man suffering from persistent bilateral ocular irritation and chronic corneal erosions. RESULTS The patient was hospitalized in our ophthalmology department and underwent thorough ophthalmic, systemic, and psyc...

AIMS Phototherapeutic keratectomy with an excimer laser is commonly used to treat recurrent corneal erosion syndrome. The aim of this study was to determine the success of a repeat phototherapeutic keratectomy for patients with persistent macroerosions following initial treatment with phototherapeutic keratectomy. METHODS Eight patients who failed primary phototherapeutic keratectomy for recu...