PURPOSE The presence of corneal opacities associated with dacryoadenitis and lacrimal gland destruction has led investigators to consider MRL/Mp mice as models for band keratopathy and Sjögren syndrome. In this study, the authors examined the time course of the corneal opacification and investigated whether the opacities were associated with altered serum levels of parathyroid hormone, calcium,...

Neovascularization is defined as formation of new vessels from vascular endothelial cells derived from existing blood vessels. These new immature vessels are friable. They have increased permeability, lack structural integrity, and can result in lipid deposition and corneal opacities. Ultrastructurally, corneal neovascularization is characterized by vessels encroaching through separated stromal...

PURPOSE Congenital stromal corneal dystrophy (CSCD) is characterized by stromal opacities that morphologically are seen as interlamellar layers of amorphous substance with small filaments, the nature of which has hitherto been unknown. CSCD is associated with truncating mutations in the decorin gene (DCN). To understand the molecular basis for the corneal opacities we analyzed the expression of...

One among the corneal diseases causing significant visual impairment and blindness is corneal dystrophies, which is a heterogeneous subset of hereditary corneal disorders that are generally bilateral, non-inflammatory and often result in corneal opacities, requiring corneal transplantation [1]. To add to this group and also which is closely related to dystrophy are the degenerative conditions o...

The anterior segments of 212 eyes (205 patients) were evaluated one to 14 years after contusional eye injuries. Anterior chamber angle recession was the commonest complication, occurring in 153 of 190 eyes examined (80.5%). However, only one patient developed ocular hypertension. Iris abnormalities were found in 37.3% of eye injured, the most common abnormalities being marginal tears and pupill...

Richner-Hanhart syndrome (tyrosinemia type II) is a rare autosomal recessive disease associated with high serum tyrosine levels caused by the deficiency of tyrosine aminotransferase enzyme. We report a 15-year-old female patient with complaints of bilateral photophobia and tearing, which started during the infancy period. Biomicroscopic examination revealed bilateral circular corneal opacities ...

PURPOSE To describe a case of secondary amyloidosis that occurred in a corneal graft. METHODS A 30-year-old Japanese woman had opacities in the corneal graft in her right eye. Slit-lamp microscopy examination demonstrated nodular, subepithelial opacities in the graft. Results of a physical examination and her past medical history were unremarkable, except for a history of a penetrating kerato...

Maeder and Datiis (1947) described a 40-year-old woman with small white curved filaments occupying a disc in the deepest layers of the corneal stroma. The peripheral 2 mm. of cornea remained unaffected. The corneae of this patient showed keratoconus, clinically manifest in the left eye with a forme fruste in the right. D'Ermo (1950) annotated a similar case in a 19-year-old girl who was also af...