PURPOSE To report the indications and techniques of corneal transplantation at a tertiary referral center in Tehran over a 3-year period. METHODS Records of patients who had undergone any kind of corneal transplantation at Labbafinejad Medical Center, Tehran, Iran from March 2004 to March 2007 were reviewed to determine the indications and types of corneal transplantation. RESULTS During th...

Corneal stroma has a significant function in normal visual function. The corneal is vulnerable because of being the thickest part cornea, as it can be affected easily by infections or injuries. Any problems on result blindness. Donor shortage for transplantation one main issues transplantation. To address this issue, tissue engineering focuses replacing injured tissues and repairing functions. ...

Purpose Severing corneal nerves during corneal transplantation does not affect first corneal transplants, but abolishes immune privilege of subsequent corneal allografts. This abrogation of immune privilege is attributable to the disabling of T regulatory cells (T regs) induced by corneal transplantation. The goal of this study was to determine if severing corneal nerves induces the development...

PURPOSE To report a keratoconic eye that developed severe sterile keratitis and corneal scar after collagen crosslinking necessitating corneal transplantation. CASE REPORT A 26-year-old man with progressive keratoconus underwent collagen crosslinking and presented with severe keratitis 72 hours after the procedure. The initial impression was infectious corneal ulcer and a fortified antibiotic...

purpose: to report the clinical findings and compare the outcomes of different surgical techniques evolved over time in a large series of patients with delayed-onset mustard gas keratitis (mgk). methods: this interventional retrospective case series includes patients with complications of delayed mgk. medical and surgical interventions to address dry eye, limbal ischemia and limbal stem cell de...

Corneal transplantation stands alone as the most common and successful form of solid organ transplantation. Even though HLA matching and systemic antirejection drugs are not routinely used, 90% of the first time corneal allografts will succeed. By contrast, all other major categories of organ transplantation require HLA matching and the use of systemically administered immunosuppressive drugs. ...

Corneal transplantation is the most frequently performed type of tissue grafting (George & Larkin, 2004). It is a highly successful treatment of severe corneal disease. However, transplantation of tissue and organs in humans has a major setback: availability of donors. To solve this, there are currently many studies on the possible use of the pig as a source of hearts, kidneys, livers, Islets o...

purpose : to evaluate indications, risk factors and outcome of repeat penetrating keratoplasty (pkp) at a tertiary referral eye care center methods : in this retrospective study, medical chart of patients who underwent repeat pkp at labbafinejad medical center between january 2004 and december 2009 were reviewed. results : a total of 1,859 corneal transplantations were performed on 1,624 eyes d...

This panorama of the immune factors in corneal graft rejection covers a spectrum of mechanisms which play a role in the opacification of corneal grafts. Great emphasis has been accorded to the role of transplantation immunity. The clinical and experimental evidence implicating transplantation immunity in the rejection of corneal grafts has been critically reviewed. In addition, evidence is pres...

Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. Methods: In 276 graft recipients who mainly underwen...