Cortisone is a steroid hormone, responsible for the stress resp, released from the adrenal gland, altered activity of the hypothalamo-pituitary-adrenal (HPA) axis is one of the most consistent findings in depression. The present investigation aimed to study the serum cortisol level in patients with major depression. Serum cortisol level was higher in depression patients 14.5±3.01μg/dl than in c...

BACKGROUND Isolated adrenocorticotropic hormone (ACTH) deficiency is a pituitary disorder characterized by reduction only in the secretion of ACTH. Although the underlying mechanism remains to be elucidated, numbers of cases with this entity have been increasing. We experienced a case presenting with gait disturbance necessitating differential diagnosis from idiopathic normal pressure hydroceph...

Given the anatomical proximity of tuberculum sellae meningioma (TSM) to the hypothalamo-pituitary system, pituitary function impairments are of great concern. We retrospectively investigated pituitary function changes following surgery in patients with TSM using pituitary provocation tests (PPTs). Thirty-one patients (27 females and 4 males) with TSM underwent initial transcranial surgery (29 p...

1. Abstract 2. Introduction 3. AP-1 as a transcription factor 4. Defining AP-1-driven gene expression in the brain: technical considerations 5. Putative AP-1 target genes 5.1. Genes encoding the transmembrane and extracellular proteins 5.1.1. Tissue inhibitor of metalloproteinases-1 (timp-1) 5.1.2. Growth-associated protein 43 (GAP-43, B50, neuromodulin, F1, PP46) 5.1.3. Angiotensin II type 1 r...

Five preterm, very low birthweight infants with severe hypotension and adrenocortical insufficiency are described. The profound hypotension was resistant to volume expansion and inotrope treatment, but responded promptly to corticosteroid treatment. A human corticotrophin releasing hormone (hCRH) test performed before corticosteroid treatment showed adequate pituitary response, and the endocrin...

The insulin test carried out with adequate safeguards under standardized conditions yields valuable information regarding hypothalamic and pituitary function when plasma levels of sugar, cortisol, and growth hormone are determined. The use of a test based on the plasma cortisol response to the infusion of lysine-vasopressin, a polypeptide with a corticotrophin-releasing action, is also of value...

The influence on pituitary function of 6 weeks of training on 6 days a week was examined in six recreational athletes. Endurance training on a bicycle ergometer for 31-33 min was performed on 4 days each week at 90-96% (weeks 1-3) and 89-92% (weeks 4-6) of the 4 mmol lactate thresholds determined on day 0 and day 21, respectively, with interval training of 3-5 x 3-5 min in addition on 2 days a ...

In recent years a novel scientific discipline called psychoneuroimmunology has emerged that examines complex interdependence of the mind, brain, endocrine and immune system in health disease. Homeostasis (a self-referral phenomenon) plays an important role keeping person healthy it fundamental host defense. Many studies show stress (acute or chronic) creates disorder especially regulation. this...