Traditionally, the notion of home crafting connotes the use of alow-techo materials and techniques; but increasingly, the once-distinct worlds of crafting and computational media have become integrated, to the mutual bene®t of both cultures. In this paper, we discuss a wide range of recurring issues in the integration of crafts and computation, drawing upon a variety of related research project...

A simple and efficient method for the synthesis of 1,1-diarylalkanes via the Friedel-Crafts-type alkylation reaction of electron-rich arenes with cinnamic acid ester derivatives or chalcones is reported. Iron triflate has been found to be the best catalyst for the Friedel-Crafts-type alkylation reaction with α,β-unsaturated carbonyl compounds. This reaction afforded β,β-diaryl carbonyl compound...

A kinetic study of DNA-based catalytic enantioselective Friedel-Crafts alkylation and Michael addition reactions showed that DNA affects the rate of these reactions significantly. Whereas in the presence of DNA, a large acceleration was found for the Friedel-Crafts alkylation and a modest acceleration in the Michael addition of dimethyl malonate, a deceleration was observed when using nitrometh...

The BF3.OEt2-catalyzed Friedel-Crafts propargylation of aromatic compounds with O-propargyl trichloroacetimidates is highly efficient and affords 1,3-diarylpropyne derivatives in good yields.

The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to...

Over the last 8 years, our laboratory has developed the concept of iminium catalysis, a mode of LUMO-lowering activation that has enabled the invention of a large number of enantioselective organocatalytic transformations including Diels-Alder cycloadditions, Friedel-Crafts alkylations, Mukaiyama-Michael additions, hydrogenations, and heteroconjugate additions.1 Central to the utility of this t...