to report the oral findings, including dental anomalies, ectopic eruption of the maxillary permanent first molars and periodontal disease and soft tissue alterations, in a subject with apert syndrome. clinical and radiographic examination of a patient with apert syndrome, aged 21 years old, not previously submitted for orthodontic or orthognathic treatment. dental anomalies were present in a pa...

Non-syndromic craniosynostosis (NSC) is a frequent congenital malformation in which one or more cranial sutures fuse prematurely. Mutations causing rare syndromic craniosynostoses in humans and engineered mouse models commonly increase signaling of the Wnt, bone morphogenetic protein (BMP), or Ras/ERK pathways, converging on shared nuclear targets that promote bone formation. In contrast, the g...

OBJECTIVE The advent of endoscopic synostectomy has enabled early surgery for infants with craniosynostosis. Even though diagnosis is often made at birth, traditionally been delayed until the infant 3 months age. There have very few published reports this procedure being performed in neonatal period. authors discuss their experience ultra-early synostectomy, defined as an operation aged 8 weeks...

RESULTS: Answers to questions were highly variable between websites with disparate statements noted, including: 1. 13% of websites state that surgery is required for all craniosynostoses. 2. 14% of websites state that if untreated, craniosynostosis mostly or always leads to developmental delay. 3. 95% of websites state there’s a combined plastic surgical-neurosurgical team approach. 5% are neur...

This review provides an overview of the state and future directions of development and pathology in the craniofacial complex in the context of Cranial Neural Crest Cells (CNCC). CNCC are a multipotent cell population that is largely responsible for forming the vertebrate head. We focus on findings that have increased the knowledge of gene regulatory networks and molecular mechanisms governing C...

RESULTS: Answers to questions were highly variable between websites with disparate statements noted, including: 1. 13% of websites state that surgery is required for all craniosynostoses. 2. 14% of websites state that if untreated, craniosynostosis mostly or always leads to developmental delay. 3. 95% of websites state there’s a combined plastic surgical-neurosurgical team approach. 5% are neur...

Introduction: Precise temporal control of cell differentiation is essential for craniofacial development. Disruptions to this process result in a range of human birth defects. For example, premature cell differentiation within the osteogenic front of cranial sutures causes craniosynostoses. Conversely, a delay in differentiation of median edge epithelium leads to clefting of the secondary palat...