haematologica | 2009; 94(10) | 1435 | The standard phase III trial These trials typically randomize approximately 400 patients between two therapies. This relatively large number is required to detect relatively small improvements with a false positive rate less than 5% (p<0.05) and a false negative rate less than 20% (80% power). For example, the trials in references 1-3 targeted increases in ...

Within the past decades, major advances in therapy for chronic myelocytic leukemia, including allogeneic hematopoietic stem cell transplantation, interferon therapy, and, more recently, also therapy with the tyrosine kinase inhibitor imatinib, have entered clinical practice. The impact of these advances on long-term survival on the population level should be disclosed as timely as possible. We ...

Acquired severe aplastic anemia is a rare disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells from unrelated donors is a treatment option frequently offered to patients after failed immunosuppressive therapy. The aim was to investigate the outcome of these patients treated with unrelated donor transplants. Systematic lite...

New measures of iron accumulation in liver and heart (superconducting quantum inference device and magnetic resonance imaging), and oral iron chelators (deferiprone and deferasirox) are available for managing iron overload in thalassemia major. To assure appropriate use of these new health technologies, the Italian Society of Hematology appointed a panel of experts to produce clinical practiceg...

most of data in multi-attribute decision making (madm) problems are changeable rather than constant and stable. therefore, sensitivity analysis after problem solving can effectively contribute to making accurate decisions. in this paper, we offer a new method for sensitivity analysis in multi-attribute decision making problems in which if the weights of one attribute changes, then we can deter...