نتایج جستجو برای: crohn
تعداد نتایج: 8465 فیلتر نتایج به سال:
Crohn disease pathogenesis is the result of the complex interaction between environmental factors (i.e. micro-flora in the gut), immunologic and genetic predisposition (1, 2). The bacterial pathogenesis hypothesis in Crohn disease is based on experimental data and clinical observation. The first studies in rodent models, such as those in transgenic HLA-B27 rats and many others in mice, demonstr...
Two patients with severe Crohn disease, defined by a Crohn Disease Activity Index (CDAI) higher than 250 despite anti-tumor necrosis factor alpha (TNF-alpha), were treated by intense immune suppression and autologous hematopoietic stem cell transplantation (HSCT). Stem cells were mobilized from the peripheral blood using cyclophosphamide (2.0 g/m2) and granulocyte colony-stimulating factor (G-C...
Crohn disease is a chronic inflammatory condition that primarily affects the gastrointestinal tract. Typical manifestations include fever, weight loss, fatigue, and abdominal pain, and abdominal abscesses and fistulae are frequent complications. Abdominal actinomycosis is a subacute or indolent disease associated with Actinomyces spp. Symptoms can be very similar to those of Crohn disease, and ...
P a t i e n t s 328 patients who were ≥ 18 years of age and had Crohn colitis or ileocolitis in complete remission (Crohn disease activity index [CDAI] ≤ 150) for ≥ 1 month before randomization. Exclusion criteria were receipt of steroid, azathioprine, or other immunosuppressive therapy within 8 weeks of the start of treatment; antibiotic therapy ≥ 1 month; potential for pregnancy or lactation;...
1Division of Gastroenterology, University of Calgary, Calgary, Alberta Correspondence and reprints: Dr Remo Panaccione, Department of Medicine, University of Calgary, Room 3621 3500 26th Avenue NE, Calgary, Alberta T1Y 6J4. Telephone 403-219-1512, fax 403-291-8017, e-mail [email protected] Received for publication May 2, 2001. Accepted May 2, 2001 R Panaccione, for the Canadian ...
INTRODUCTION Despite optimized medical treatment, Crohn´s disease can cause gastrointestinal (GI) strictures, which requires surgical intervention. Lately, endoscopic balloon dilatation has been established as an alternative to surgery. In the following, we report our experiences with endoscopic dilatation of strictures in the gastrointestinal tract caused by Crohn´s disease. MATERIAL AND MET...
BACKGROUND Oral localization of Crohn disease is uncommon and must be differentiated from nonspecific lesions. Its natural course and its long-term prognosis are unknown. OBSERVATIONS We studied 9 patients (8 male, 1 female; age range, 7-52 years; median age, 16 years) with Crohn disease and specific oral lesions, including deep linear ulcers, pseudopolyps, and/or labial or buccal swelling an...
BACKGROUND It has long been believed that breastfeeding provides protection against ulcerative colitis and Crohn disease. Studies designated to test this hypothesis were conducted without reaching conclusive results. OBJECTIVE The aim of this meta-analysis was to examine the role of breastfeeding in preventing inflammatory bowel disease and to summarize the evidence gathered about this subjec...
OBJECTIVE a strong association has been observed between celiac disease, generally its silent clinical form, and autoimmune disorders. A potential correlation with inflammatory bowel disease has also been suggested. Anti-tissue transglutaminase antibodies have been detected in Crohn´s disease. We investigated the prevalence of celiac disease in patients with autoimmune diabetes and in Crohn´s d...
IMPORTANCE Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. OBJECTIVE To evaluate the effect of autologous HSCT on refractory Crohn disease. DESIGN, SETTING, AND PARTICIPANTS Parallel-group randomized clinical trial conducted in 11 European transplant units from July 2007 to September 2011, with follow-up through Ma...
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