Interpenetrating polymer network of cross-linked blend microspheres for controlled release Acebutolol HClP. Ramakrishna, B. Mallikarjuna, A. Chandra Babu, P. Sudhakar, K. Chowdoji Rao, M.C.S. Subha

Interpenetrating polymer network of cross-linked blend microspheres for controlled release Acebutolol HClP. Ramakrishna, B. Mallikarjuna, A. Chandra Babu, P. Sudhakar, K. Chowdoji Rao, M.C.S. Subha

Using recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) as a model drug, the present study demonstrated a practically feasible process to produce polymeric microspheres for sustained-release delivery of protein drugs with preserved integrity. This process is featured with pre-loading proteins into polysaccharide fine particles via a self-standing aqueous-aqueous "emu...

The cause of initial burst release of hydrophilic macromolecular drugs from biodegradable polymeric microspheres was identified. Poly(D,L-lactic-co-glycolic acid) microspheres encapsulating fluorescein isothiocyanate (FITC)-labled dextran was prepared by a double emulsion solvent evaporation method. The extent of initial burst release was examined by varying the formulation process conditions s...

Interpenetrating polymer network of cross-linked blend microspheres for controlled release Acebutolol HClP. Ramakrishna, B. Mallikarjuna, A. Chandra Babu, P. Sudhakar, K. Chowdoji Rao, M.C.S. Subha

There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using ...

Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...

Starch or dextran blue microspheres were transferred microsurgically to the infundibulum of the oviduct on Days 1, 2, or 3 of pregnancy of control and oestradiol-treated rats. The animals were killed a few hours to several days after transfer to assess the number and distribution of ova and microspheres in the tract. After transfer on Day 1 of pregnancy, microspheres and eggs crossed the ampull...