نتایج جستجو برای: crossover design

تعداد نتایج: 984879  

2002
Chien-Feng Chen Jie Huang Eli Lilly

Crossover designs are efficient alternatives to parallel designs. Sample size reduction, comparing the 2x2 crossover to a two-arm parallel study, is approximately 4 to 1 in diabetes clinical trials. One challenge of using a crossover design is understanding and handling potential carryover effects. This paper will review the fundamentals of the crossover design, including design, model, and ana...

Journal: :Polibits 2015
Miguel Gabriel Villarreal-Cervantes Daniel De-la-Cruz-Muciño Carlos Ricaño-Rea Jesus Said Pantoja-García

Differential evolution (DE) is a powerful algorithm to find an optimal solution in real world problems. Nevertheless, the binomial crossover parameter is an important issue for the success of the algorithm. The proper selection of the binomial crossover parameter depends on the problem at hand. In this work, the effect of the binomial crossover in the DE/Rand/1/bin, DE/Best/1/Bin and DE/Current...

Journal: :Evolutionary computation 2007
Alberto Moraglio Yong-Hyuk Kim Yourim Yoon Byung Ro Moon

Geometric crossover is a representation-independent generalization of the traditional crossover defined using the distance of the solution space. By choosing a distance firmly rooted in the syntax of the solution representation as a basis for geometric crossover, one can design new crossovers for any representation. Using a distance tailored to the problem at hand, the formal definition of geom...

Journal: :مجله دانشکده پزشکی دانشگاه علوم پزشکی تهران 0
غلامرضا درخشان دیلمی derakhshan deilami gh سمراد محرابی mehrabi s

despite the role of oral corticosteroids in management of sever asthma, use of these drugs needs careful awareness of its many side effects. there are controversies about the role of methotrexate in lowering the need for corticosteroides in these patients. in this study an attempt has been made to determine methotrexate effects in corticosteroid dependent asthma. six patients were entered in a ...

2000
Alex S. Fraser David B. Fogel

Several recombination operators have been proposed in evolutionary computation. Standard procedures include one-point, two-point, and uniform crossover. Little attention, however, has been given to a recombination operator that preceded each of these, which was offered in 1957 by Alex Fraser. Fraser’s recombination assigns a variable probability for crossing over between two solutions at each l...

Journal: :Journal of biopharmaceutical statistics 2002
Hansheng Wan Shein-Chung Chow

In its recent guidance on bioequivalence, the U.S. Food and Drug Administration (FDA) recommends a two-sequence, four-period (2 x 4) replicated crossover design be used for assessment of population and individual bioequivalence [FDA. Guidance for Industry on Statistical Approaches to Establishing Bioequivalence; Center for Drug Evaluation and Research, Food and Drug Administration: Rockville, M...

2012
Nicholas G. Reich Jessica A. Myers Daniel Obeng Aaron M. Milstone Trish M. Perl

In recent years, the number of studies using a cluster-randomized design has grown dramatically. In addition, the cluster-randomized crossover design has been touted as a methodological advance that can increase efficiency of cluster-randomized studies in certain situations. While the cluster-randomized crossover trial has become a popular tool, standards of design, analysis, reporting and impl...

2017
Maryam Safarkhani Mirjam Moerbeek

Crossover designs are well-known to have major advantages when comparing the effects of various non-curative treatments. We compare efficiencies of several crossover designs along with the Balaam’s design with that of a parallel group design pertaining to longitudinal studies where event time can only be measured in discrete time intervals. With equally sized sequences, the parallel group desig...

Journal: :Asian Journal of Applied Science and Technology 2020

Journal: :International Journal of Occupational Medicine and Environmental Health 2011

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