Background: Croton oil is the only commercial source of the diterpenoid phorbol (1a), the starting material for the semi-synthesis of various diesters extensively used in biomedical research to investigate cell function and to evaluate in vivo anti-inflammatory activity. While efficient chemoselective esterification protocols have been developed for phorbol, its isolation from croton oil is tec...

The ability of croton oil to elicit epithelial tu mors in mice in areas previously treated with subcarcinogenic amounts of carcinogenic hydrocar bons is a well documented fact. In the typical ex periment tumors are initiated in the skin of mice by the single application of a solution of some car cinogenic hydrocarbon at a level that induces few if any tumors. The repeated application of croton ...

In a previous communication (5), the author has shown that when the effective carcinogenic potency of 3,4-benzpyrene for the mouse's skin was reduced by application of the hydrocarbon in a dilution ot~ o.o 5 per cent, the low tumor yield (o to 6 per cent at the 2oth week) was increased to 80 per cent by application of croton resin concurrently with the benzpyrene. 1 This augmentation of carcino...

Croton é um gênero de Euphorbiaceae com cerca de 1300 espécies, amplamente distribuídas em regiões tropicais do Novo e Velho Mundos. Várias espécies há muito tempo desempenham papel importante nos usos tradicionais de plantas medicinais na África, Ásia e América do Sul. Tais usos incluem tratamento de câncer, constipação intestinal, diarréia e outros problemas digestivos, diabetes, feridas exte...

The importance of DNA synthesis in the initiation of skin tumorigenesis by urethan was investigated. Treatment of mice with 0.5% croton oil increases the rate of epidermal DNA synthesis 3to 6-fold beginning at 9 to 12 hr, reaching a peak at 18to 24 hr, and remaining elevated for 3 to 4 days. Croton oil treatment times of -24, -6, +1, and +24 hr were tested for their effect on initiation of skin...

In a previous communication (5), the author has shown that when the effective carcinogenic potency of 3,4-benzpyrene for the mouse's skin was reduced by application of the hydrocarbon in a dilution ot~ o.o 5 per cent, the low tumor yield (o to 6 per cent at the 2oth week) was increased to 80 per cent by application of croton resin concurrently with the benzpyrene. 1 This augmentation of carcino...

Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark and leaf infusion of this plant have been popularly used to treat diabetes and hepatic disorders. The present study was designed to evaluate the oxidative stress as well as the therapeutic effect of Croton cajucara Benth (1.5 mL of the C. cajucara extract i.g.) in rats with streptozotocin-induced diabetes. Croton cajucara B...

This article conta ined descriptions of five new taxa of Mexican Euphorbiaceae. Euphorbia (sub g. Agaloma) na yarensis is endemic to pine-oak woodland in the mount ains of central Nayarit. It appears related to E. so ob yi but differs by possessing linear to linear-ovate leaves. Croton varelae is also endemic to central Nayarit. A key was provided to distinguish this spec ies. a member of sect....