background liver cirrhosis is one of the major causes of hospitalization and mortality in children. a wide spectrum of disorders including developmental abnormali­ties, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. determination of its etiology is important for treatment mo­dality, prevention of progressive liver damage, family counseling and pri...

Cirrhosis is defined as the advanced stages of hepatic fibrosis, with characteristic distortion of the hepatic architecture in addition to numerous regenerative nodules. Cirrhosis without an apparent cause is labeled cryptogenic (1, 2). Since metabolic syndrome was identified as a distinct medical entity, and insulin resistance and hyperinsulinemia have been addressed as its fundamental pathoph...

BACKGROUND Hepatitis B virus (HBV) infection is a worldwide public health problem. Nine HBV genotypes (A-I) have been already discovered. HBV genotypes are important both in the clinical manifestation of disease and treatment response. Moreover, HBV DNA without HBs (Hepatitis B surface)-antigenemia was detected in some patients with chronic hepatitis (occult hepatitis). There is little informat...

The incidence of hepatocellular carcinoma (HCC) in the United States is increasing, but the clinical characteristics of American patients with HCC have not been well described. The aims of this study were to determine the etiology of liver disease and short-term outcome among HCC patients presenting to a single center in the United States. One hundred five consecutive patients with HCC were stu...

Most patients with alpha1 antitrypsin deficiency do not receive this diagnosis until developing severe complications, in particular when respiratory symptoms are absent. This is a reason for making alpha1 antitrypsin deficiency a possible diagnosis among patients with cryptogenic cirrhosis or other conditions of liver disease without a clear etiology. In this report, a case of cryptogenic cirrh...

A total of 512 people from a defined population in west Birmingham served by a district general hospital were found to have cirrhosis in the period 1959-76. The annual incidence rose from 5.6 per 100 000 to a peak of 15.3 per 100 000 in 1974. This was due to an increase in the incidence of alcoholic cirrhosis, which in the last six years accounted for two-thirds of cases. The proportion of pati...

Though the first documented case was described by Jaksch-Wartenhorst (1923), the name 'relapsing polychondritis' was suggested by Pearson, Kline and Newcomer as late as 1960. The extreme rarity of the condition and its possible confusion with other common conditions in Bangladesh, for example, leprosy, gout and pyogenic conditions of the pinna prompted us to report this case. In addition, the p...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease. Hepatocellular carcinoma (HCC) is one of its complications. Although the pathophysiology is unclear, it is reasonable to expect that cryptogenic cirrhosis related HCC (cryptogenic HCC) behaves differently to other types of HCC. This study prospectively compared patients with cryptogenic HC...