Expression of CXCR4 in cancer has been found to correlate with poor prognosis and resistance to chemotherapy. In this study we developed a derivative of the CXCR4 peptide antagonist, T140-2D, that can be labeled easily with the PET isotope copper-64, and thereby enable in vivo visualization of CXCR4 in tumors. T140 was conjugated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono ...

Abstract Artemisia absinthium L. is a highly medicinal plant with broad range of biomedical applications. A. callus cultures were established in response to bio-fabricated single NPs (Ag and Cu) or combination both different ratios (1:2, 2:1, 1:3, 3:1) along thidiazuron (TDZ) (4 mg/L) elicit the biomass accumulation, production non-enzymatic compounds, antioxidative enzymes, antioxidant activit...

Toxicity tests were conducted with the marine copepod Acartia tonsa to assess the effects of dietary metal exposure. The diatom Thalassiosira pseudonana was cultured with Ag, Zn, Cu, or Ni and used as diets for adult A. tonsa over a 7-d exposure, and copepod survival and reproduction were measured throughout the exposure period. For all metals, reproduction was the most sensitive endpoint, with...

The structure of a blue copper protein, cupredoxin, from the potent denitrifying bacterium Alcaligenes faecalis S-6, has been determined and refined against 2 A x-ray diffraction data. The agreement between observed and calculated structure factors is 0.159, and estimated errors in coordinates are 0.09-0.15 A. The protein folds in a beta sandwich similar to plastocyanin and azurin and includes ...

Ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and other synthetic polycarboxylic acids have been shown to possess substantial capacity as washing agents of heavy metal-polluted soils, but they are environmentally problematic. Therefore, a sample of natural soluble humic substances (HS) was tested as a possible substitute. The efficiency of HS to extract cadmium (Cd), copp...

In this study, a self-designed simultaneous crossflow electrocoagulation/electrofiltration (EC/EF) treatment module was evaluated for its overall reatment performance by treating chemical mechanical polishing (CMP) wastewaters including Cu-CMP wastewater and oxide-CMP wastewater. he critical electric field strengths for Cu-CMP and oxide-CMP wastewaters were determined to be 35 and 30 V/cm, resp...