نتایج جستجو برای: cuneiformis nucleus cnf
تعداد نتایج: 114052 فیلتر نتایج به سال:
Objective(s): The 5-hydroxytryptamine1A (5-HT1A) receptor is one of the serotonin receptors in the brain, which regulates cardiovascular responses, especially in hemorrhage. Presence of this receptor in the cuneiform nucleus (CnF) has been shown. The present study evaluates the cardiovascular effect of this receptor of the CnF in normal and hypotensive hemorrhagic rats...
زمینه و هدف: هسته های میخی شکل (cuneiformis: cnf) موجود در ناحیه بطنی جانبی ماده خاکستری دور کانالی (periaqueductal gray: pag)، دارای گیرنده های مخدر مانندی (opioid) هستند که در تعدیل درد شدید نقش دارند. مطالعه حاضر با هدف ارزیابی تاثیر تزریق درون هسته ای مرفین در ناحیه cnf مغز موش صحرایی بر تغییر درد مزمن و نقش ضد احساس درد آن (antinociceptive) انجام شد. روش تحقیق: در این مطالعه تجربی، از 40 س...
BACKGROUND Attrition rates of new analgesics during drug development are high; poor assay sensitivity with reliance on subjective outcome measures being a crucial factor. METHODS The authors assessed the utility of functional magnetic resonance imaging with capsaicin-induced central sensitization, a mechanism relevant in neuropathic pain, for obtaining mechanism-based objective outcome measur...
background: the presence of nitric oxide (no) in the cuneiform nucleus (cnf) has been previously shown. in this study, ng-nitro-l-arginine methyl ester (l-name) (an inhibitor of no synthase), l-arginine (l-arg) (a precursor of no), and sodium nitroprusside (snp) (a donor of no) were microinjected into the cnf and cardiovascular responses were investigated. methods: seventy male rats were divide...
Neuroimaging methods have so far identified various structures in the brain involved in the processing of pain and its control. However, our understanding of their anatomical connectivities is relatively weak. Diffusion tensor imaging (DTI), a magnetic resonance imaging-based method, allows in vivo mapping of the anatomical connections in the human brain and was used to investigate the white ma...
Evidence from both human and animal studies has demonstrated a key role for brainstem centers in the control of ascending nociceptive input. Nuclei such as the rostral ventromedial medulla and periaqueductal gray (PAG) are able to both inhibit and facilitate the nociceptive response. It has been proposed that altered descending modulation may underlie many of the chronic pain syndromes (both so...
A B S T R A C TIntroduction: The nucleus cuneiformis (NCF) and ventrolateral periaqueductal gray (vlPAG), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (NRM). Methods: This study examined whether the antinociceptive effect of morphine microinjected into the NCF is influenced by inactivation of vlPAG and NRM in rats. Animals were bilaterally micr...
Several lines of evidence over the last few years have been important in ascertaining that the pedunculopontine nucleus (PPN) region could be considered as a potential target for deep brain stimulation (DBS) to treat freezing and other problems as part of a spectrum of gait disorders in Parkinson disease and other akinetic movement disorders. Since the introduction of PPN DBS, a variety of clin...
Background: The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods: Seventy male rats were divide...
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