objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

Description Curcuma longa, a perennial herb and member of the Zingiberaceae (ginger) family, grows to a height of three to five feet and is cultivated extensively in Asia, India, China, and other countries with a tropical climate. It has oblong, pointed leaves and funnel-shaped yellow flowers.1 The rhizome, the portion of the plant used medicinally, is usually boiled, cleaned, and dried, yieldi...

Purpose Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA). Having previously demonstrated that curcuminoid-only and essential oil-only fractions of turmeric prevent joint destruction in an animal model of RA, we hypothesized that synoviocyte PTHrP production could be one signaling pathway ...

Oral feeding of 50% EtOH extract of Curcuma longa to male rats at the dose of 1gm/kg body weight caused significant reduction of serum cholesterol, triglycerides and phospholipids (P≤0.01 to 0.001). Whereas the SGOT levels aware not reduced significantly. Fertility test showed 80% negative result. The negative fertility results reflects the arrest of spermatogenesis and depletion of androgen le...

Azadirachta indica and Curcuma longa is the most useful traditional plant being used in India for medicinal purposes from centuries. There is evidence that these plants have anti-inflammatory, analgesic, antipyretic, antioxidant and anticancer activities. Work has been done on the wound-healing and anti-inflammatory activities of these plants and investigation is needed to understand the mechan...

We explored, using nuclear magnetic resonance (NMR) metabolomics and fatty acids profiling, the effects of a common nutritional complement, Curcuma longa, at a nutritionally relevant dose with human use, administered in conjunction with an unbalanced diet. Indeed, traditional food supplements have been long used to counter metabolic impairments induced by unbalanced diets. Here, rats were fed e...

The aim of this systematic review is to summarize the evidence for or against the efficacy of plant food supplements (PFS) for coping inflammatory conditions by considering epidemiological and human intervention studies. The review considers six botanical species commonly used as food supplements/medicinals: Urtica dioica L., Symphytum officinalis L., Calendula officinalis L., Curcuma longa L.,...

Knee effusion is an abnormal accumulation of the fluid in the knee capsule or the adjoining supra-patellar bursa secondary to the irritation/inflammation in the joint synovium. It is seen in approximately 8-10 % of the total patients suffering from osteo-arthrosis. Kroṣṭukaśīrṣaas described in Ayurveda, can be corelated with knee effusion. In Present clinical trial an effort has been made to ev...

Aim: The present investigation has been conducted to evaluate the hepatoprotective effect of Curcuma longa against lead induced toxicity. Materials and Methods: For this study, 24 Wistar albino rats were taken. Control group (n=8), group – I rats (n=8) were given lead acetate @ 1000 mg/kg bodyweight (BW) and group – II rats (n=8) were treated with Curcuma longa @ 500 mg/kg BW along with lead ac...