Low-density lipoprotein (LDL) cholesterol (LDL-C) is a risk factor for cardiovascular disease (CVD). Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) lower LDL-C concentrations by about 30–50% and have been shown to reduce mortality in patients with prevalent CVD. However, it is not clear whether statin treatment is benefi cial in a primary prevention setting, that is in peo...

The search for complementary treatments in primary prevention of cardiovascular disease (CVD) is a high-priority challenge. Grape and wine polyphenol resveratrol confers CV benefits, in part by exerting anti-inflammatory effects. However, the evidence in human long-term clinical trials has yet to be established. We aimed to investigate the effects of a dietary resveratrol-rich grape supplement ...

Relevance to family physicians Cardiovascular disease (CVD) is the leading cause of death in Canada. In men of all ages, 36% of deaths are attributable to CVD. In women, the percentage is slightly higher at 38%.1 Acetylsalicylic acid is widely prescribed for prevention and treatment of CVD and is one of the most widely used pharmacologic agents in the United States.2 Five large randomized contr...

OBJECTIVE To determine the cost-effectiveness of a worksite-based naturopathic (individualized lifestyle counseling and nutritional medicine) approach to primary prevention of cardiovascular disease (CVD). METHODS Economic evaluation alongside a pragmatic, multi-worksite, randomized controlled trial comparing enhanced usual care (EUC; usual care plus biometric screening) to the addition of a ...

BACKGROUND Older patients with longstanding type 1 diabetes have high cardiovascular disease (CVD) risk such that statin therapy is recommended independent of prior CVD events. We aimed to determine self-reported CVD prevention guideline adherence in patients with longstanding diabetes. RESEARCH DESIGN AND METHODS 309 Canadians with over 50 years of type 1 diabetes completed a medical questio...

Corresponding author: Bo Kyung Koo Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 156-707, Korea E-mail: [email protected] Stain is commonly used in subjects with diabetes for both primary and secondary prevention of cardiovascular diseases (CVDs) [1,2]. It is even recommended by the American Di...

OBJECTIVES To analyse the association between refill adherence to lipid-lowering medications, and the risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes mellitus. DESIGN Cohort study. SETTING National population-based cohort of Swedish patients with type 2 diabetes mellitus. PARTICIPANTS 86 568 patients aged ≥18 years, registered with type 2 diabetes melli...

significant decline in cardiovascular mortality and morbidity has been achieved with the improvements in detection and prevention programmes for major risk factors (such as smoking, low physical activity levels, obesity, and high blood pressure) related to cardiovascular disease (CVD). However, CVD still remains the leading cause of mortality and disability in the world. Collectively, ischaemic...

OBJECTIVE The use of low-dose aspirin for primary prevention of cardiovascular events in patients at elevated risk for cardiovascular disease (CVD) is increasingly being questioned. Aspirin may not benefit this population and may increase the risk of major bleeding events. Data support aspirin use in patients with known CVD. METHODS This is a secondary analysis of de-identified electronic hea...

BACKGROUND Individuals infected with human immunodeficiency virus (HIV) are at increased risk for cardiovascular disease (CVD) events compared with uninfected persons. However, little is known about HIV provider practices regarding aspirin (ASA) for primary prevention of CVD. METHODS A cross-sectional study was conducted among patients attending the University of Alabama at Birmingham 1917 HI...