INTRODUCTION Gastric cancer is one of the most common cancer-related causes of death. This is mainly due to the lack of good noninvasive method/biomarkers suitable for early-tumour diagnosis and planning of further therapy modalities. Chemokines play an important role in cancer progression and metastasis formation. In gastric cancer patients, clinical relevance of CXCL12 and CCL5 level has been...

objective(s): the impact of fasting in ramadan as a unique type of nutritional regimen on biochemical and hematological parameters is still an issue of debate. almost very little is known regarding the regulatory role(s) of this nutritional status on immune responses or inflammation.   materials and methods:   the levels of biochemical parameters were determined using commercial diagnostic kits...

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

background: genetic variation influences susceptibility/resistance to tuberculosis. cxcl10 is involved in t-cell migration and stimulation of natural killer cells in mycobacterium tuberculosis infection. objectives: we aimed to investigate the genetic polymorphisms in promoter of the cxcl10 gene in patients with pulmonary tuberculosis (ptb) and healthy controls, to clarify whether polymorphisms...

Airway smooth muscle (ASM) cells play a critical role in the pathophysiology of asthma due to their hypercontractility and their ability to proliferate and secrete inflammatory mediators. microRNAs (miRNAs) are gene regulators that control many signaling pathways and thus serve as potential therapeutic alternatives for many diseases. We have previously shown that miR-708 and miR-140-3p regulate...

The receptor and the receptor axis CXCL12 / CXCR4 are the two pairs studied in the metastasis of breast cancer. The purpose of this study was to investigate the relationship between the occurrence of CXCR4 / CXCL12 genes polymorphism and the clinical and pathological characteristics of patients with metastatic breast cancer under chemotherapy. Material and methods: Genomic DNA was extracted f...