1. The heterogeneity of cytochrome c obtained in the monomeric form from different organs of rat was studied. Disc electrophoresis on polyacrylamide gel ievealed the presence of four forms in heart muscle, liver, and kidney. In the kidney, the mean percentage distribution was Cy I 86.2 %, Cy II S.O%, Cy III 4.2%, and Cy IV 1.6%. 2. The rate at which radioactive iron (SYFe) is incorporated into ...

1. The heterogeneity of cytochrome c obtained in the monomeric form from different organs of rat was studied. Disc electrophoresis on polyacrylamide gel ievealed the presence of four forms in heart muscle, liver, and kidney. In the kidney, the mean percentage distribution was Cy I 86.2 %, Cy II S.O%, Cy III 4.2%, and Cy IV 1.6%. 2. The rate at which radioactive iron (SYFe) is incorporated into ...

From March 1988 to March 1991, 19 French bone marrow transplant (BMT) centers participated in a prospective randomized trial comparing two conditioning regimens for patients with chronic myeloid leukemia transplanted in first chronic phase with an HLA identical sibling donor. A total of 120 consecutive patients were randomized to receive either 120 mg/kg of cyclophosphamide followed by total bo...

Weaning pigs (7.9 +/- 1.7 kg) were fed a freeze-dried powder of marionberry (MB) by stomach tube to study the absorption and metabolism of anthocyanins. Four major anthocyanins (ACNs) were found in MB: cyanidin-3-glucoside (Cy-3-glc, 78%), cyanidin-3-rutinoside (Cy-3-rutin, 20%), pelargonidin-3-glucoside (Pg-3-glc, 0.4%), and 1 unknown acylated cyanidin-based ACN (UACy, 1.5%). In the urine, the...

Preclinical studies of resistance to alkylating agents in the Lewis x Brown Norway hybrid (LBN) rat model of acute myeloid leukemia (AML) have hitherto been limited by the sensitivity of LBN AML cells to cyclophosphamide (CY). We developed a CY-resistant subline of LBN AML by serial intravenous (IV) passage of AML cells followed by in vivo exposure to CY (100 mg/kg) 14 days later. After 18 and ...

BACKGROUND The prognosis for patients with scirrhous gastric cancer (SGC) is extremely poor. However, the management protocol for this type of cancer has not been well discussed. In this study, we retrospectively evaluated the management of SGC and we introduced a new treatment protocol for SGC. PATIENTS AND METHODS Between 1991 and 2001, 58 patients with SGC were treated. Thirty-nine, who un...

Peripheral blood progenitor cell mobilization with intermediate-dose cyclophosphamide (ID-CY) and granulocyte colony-stimulating factor (G-CSF) has been shown to be more efficacious, albeit more toxic, than low-dose cyclophosphamide (LD-CY) mobilization regimens in patients with multiple myeloma treated with conventional therapies. However, the relative importance of cyclophosphamide dose inten...

The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria wer...

In the early 1990s, 4 randomized studies compared conditioning regimens before transplantation for leukemia with either cyclophosphamide (CY) and total-body irradiation (TBI), or busulfan (Bu) and CY. This study analyzed the long-term outcomes for 316 patients with chronic myeloid leukemia (CML) and 172 patients with acute myeloid leukemia (AML) who participated in these 4 trials, now with a me...

We have demonstrated that hydrocortisone (HC) enhances the antitumor action of cyclophosphamide (CY). When sar coma-bearing C57BL/6J, BALB/cByJ, and C3H/HeJ mice were given a single injection i.p. of CY (300 mg/kg), followed 1 to 3 days later by a s.c. injection of HC (10 mg in 0.1 ml of incomplete Freund's adjuvant), there was a dramatic acceler ation of the reduction in tumor size compared wi...