The endothelial lining of the vasculature is exposed to a large variety of biochemical and hemodynamic stimuli with different gradients throughout the vascular network. Adequate adaptation requires endothelial cells to be highly plastic, which is reflected by the remarkable heterogeneity of endothelial cells in tissues and organs. Hemodynamic forces such as fluid shear stress and cyclic strain ...

In this paper, an elastoplastic constitutive model is presented for predicting sandy soil behavior under monotonic and cyclic loadings. The model is based on the CJS3 model that takes into account deviatoric and isotropic mechanisms of plasticity. The flow rule in deviatoric mechanism is non-associated and a kinematic hardening law controls the evolution of the &#10yield surface. In the present...

The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...

The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...

Transcriptional changes in neurons underpin the long-lived cellular response to environmental stimuli, and cAMP-responsive element-binding protein (CREB1) has been implicated in this process. Exposure to psychostimulants such as cocaine results in persistent neuronal plasticity in cortical circuitry that likely modulates the motivation to use the drug again. To examine whether CREB1 in cortical...

In this paper, an elastoplastic constitutive model is presented for predicting sandy soil behavior under monotonic and cyclic loadings. The model is based on the CJS3 model that takes into account deviatoric and isotropic mechanisms of plasticity. The flow rule in deviatoric mechanism is non-associated and a kinematic hardening law controls the evolution of the yield surface. In the present s...