In the field of molecular modeling, docking may be a method which predicts well-liked orientation any molecule to receptor make stable complex. Knowledge successively could also able predict strength association or binding affinity between two molecules using, for instance, scoring functions. Cyclooxygenase-2 (COX-2) inhibitors block cyclooxygenase-2 (COX-2), an enzyme that promotes inflammatio...

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...

This study aimed to examine the chemical composition of wheat germ oil extracted by three different methods, and evaluate its inhibitory effect on cyclooxygenase proteinase activities. The results showed that contents policosanols, tocopherols phytosterols were affected extraction procedure. However, fatty acid extracts was nearly same. Among tested oils samples, cold pressed exhibited stronges...