نتایج جستجو برای: cyp2c19 polymorphisms

تعداد نتایج: 68456  

2017
Adel A. Alhazzani Murali Munisamy Gauthaman Karunakaran

OBJECTIVE To elucidate the degree of genetic polymorphisms CYP2C19 (CYP2C19*2, CYP2C19*3) of key drug metabolizing enzymes on the antiplatelet effect of clopidogrel response in patients with acute ischemic stroke from Saudi Arabia. METHODS A case-control study carried out at Neurology Clinics at Asser Central Hospital, Abha, Kingdom of Saudi Arabia from October 2015 to January 2016 and includ...

Journal: :Xinan Jiaotong Daxue Xuebao 2023

This study aims to investigate CYP2C19 gene polymorphisms and the association between with cardiovascular risk factors major adverse events (MACE) in patients acute myocardial infarction (AMI). A prospective cross-sectional analysis involved 86 AMI enrolled assessed MACE evaluated after three months of treatment. CYP2C19*1*1 genotype accounted for highest prevalence at 54.7%, which means normal...

Journal: :Chinese medical journal 2013
Xiao-Fang Tang Jia-Hui Zhang Jing Wang Ya-Ling Han Bo Xu Shu-Bin Qiao Yong-Jian Wu Jue Chen Yuan Wu Ji-Lin Chen Run-Lin Gao Yue-Jin Yang Jin-Qing Yuan

BACKGROUND The CYP2C19 G681A single polymorphism has been proven to affect clopidogrel responsiveness. However, the effect of coexisting polymorphisms of other genes has not yet been reported in the Chinese population. This study investigated the effect of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel responsiveness and adverse clinical events in Chinese patients. METHODS In 57...

Journal: :Pharmacotherapy 2010
Kathryn M Momary Michael P Dorsch Eric R Bates

Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel responsiveness. Drug interactions with and genetic variation in CYP3A4, CYP3A5, a...

Journal: :journal of research in medical sciences 0
xiaodong wang yan lai yu luo xumin zhang hua zhou zi ye

background: this study was designed to investigate the eff ect of clopidogrel-related gene polymorphisms on platelet reactivity and clinical outcome in chinese han patients. materials and methods: th ree hundred and thirty-six percutaneous coronary intervention - treated patients were recruited and followed for 1 year. blood samples were collected from all patients for dna genotyping. th e plat...

2016
Geik Yong Ang Choo Yee Yu Vinothini Subramaniam Mohd Ikhmal Hanif Abdul Khalid Tuan Azlin Tuan Abdu Aziz Richard Johari James Aminuddin Ahmad Thuhairah Abdul Rahman Fadzilah Mohd Nor Adzrool Idzwan Ismail Kamarudzaman Md. Isa Hood Salleh Lay Kek Teh Mohd Zaki Salleh

The human cytochrome P450 (CYP) is a superfamily of enzymes that have been a focus in research for decades due to their prominent role in drug metabolism. CYP2C is one of the major subfamilies which metabolize more than 10% of all clinically used drugs. In the context of CYP2C19, several key genetic variations that alter the enzyme's activity have been identified and catalogued in the CYP allel...

2013
Montri Chamnanphon Khunthong Pechatanan Ekapob Sirachainan Narumol Trachu Wasun Chantratita Ekawat Pasomsub Wilai Noonpakdee Insee Sensorn Chonlaphat Sukasem

PURPOSE To investigate the impact of CYP2D6 and CYP2C19 polymorphisms in predicting tamoxifen efficacy and clinical outcomes in Thai breast cancer patients. METHODS Polymorphisms of CYP2D6 and CYP2C19 were genotyped by the AmpliChip™ CYP450 Test (Roche Molecular Diagnostics, Branchburg, NJ, USA) for 57 patients, who were matched as recurrent versus non-recurrent breast cancers (n = 33 versus ...

Journal: :Drug metabolism and pharmacokinetics 2013
Takeshi Hirota Shunsuke Eguchi Ichiro Ieiri

Human cytochrome P450 (CYP) is a superfamily of hemoproteins which oxidize a number of endogenous compounds and xenobiotics. The human CYP2C subfamily consists of four members: CYP2C8, CYP2C9, CYP2C18 and CYP2C19. CYP2C9 and CYP2C19 are important drug-metabolizing enzymes and together metabolize approximately 20% of therapeutically used drugs. Forty-two allelic variants for CYP2C9 and 34 for CY...

2016
Xiang-Long Liu Qiu-Ju Jia Li-Na Wang Zong-Ming Liu Hai Liu Xuan-Chu Duan Xue-Man Lyu

BACKGROUND The aim of this study was to investigate the roles of cytochrome P450 2C19 (CYP2C19) polymorphisms in primary open-angle glaucoma (POAG) susceptibility and individual responses to drug treatment. MATERIAL/METHODS This case-control study consisted of 93 cases with POAG and 125 controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze...

2014
Ming Chang Ulrika Simonsson

Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. Of the many factors causing variability in drug response across individuals, genetic polymorphism of drug-metabolizing enzymes is deemed to be one of the ...

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