نتایج جستجو برای: cyproterone derivatives
تعداد نتایج: 105840 فیلتر نتایج به سال:
Cosignatories Jean-Jacques Amy, Rob Beerthuizen, Martin Birkhäuser, Teresa Bombas, Mitchell Creinin, Philip D Darney, Lisa Ferreira Vicente, Kristina Gemzell-Danielsson, Bruno Imthurn, Jeffrey T Jensen, Andrew M Kaunitz, Ali Kubba, Medard M Lech, Diana Mansour, Gabriele Merki, Thomas Rabe, Katarina Sedlecki, David Serfaty, Jacques Seydoux, Lee P Shulman, Regine Sitruk-Ware, Sven O Skouby, Anne ...
LNCaP cells (derived from a lymph node carcinoma of the human prostate) show androgen responsive growth. Progestagens, estradiol and antiandrogens competed with androgens for binding to the androgen receptor in the cells to a higher extent than in other androgen-sensitive systems. Optimal growth (3-4 fold increase in DNA content of 6 day cell cultures vs controls) was observed after addition of...
BACKGROUND Picralima nitida seed extract (PNE) has aphrodisiac and contraceptive effect. AIM To investigate the effect of PNE on reproductive hormones. MATERIALS AND METHODS The size and length of the combs of white leghorn day-old chicks treated with testosterone (0.5-1.5 mg/kg), cyproterone (3-30 mg/kg), or PNE (50-500 mg/kg) for 7 days, as well as cyproterone (10, and 30 mg/kg) on PNE-in...
BACKGROUND In advanced prostate cancer, androgen suppression (AS) by surgery or drugs controls testicular hormone secretion, and the further addition of an antiandrogen such as nilutamide, flutamide, or cyproterone acetate is referred to as maximum androgen blockade (MAB). The aim of this overview was to compare the effects on the duration of survival of MAB and of AS alone. METHODS The colla...
In whole cells, the effects of several androgens and antiandrogens on the in the induction of DNA binding for the human wild-type androgen receptor (AR) and a mutant receptor ARL (LNCaP mutation; codon 868, Thr to Ala) were examined and related to the transcription activation ability of these receptors. To study DNA binding, an AR expression vector was cotransfected in Chinese hamster ovary cel...
Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism for benzene derivatives on metal surfaces, enabling us to selectively tune the...
OBJECTIVES The antischistosomal properties of the marketed antiandrogens bicalutamide, flutamide, nilutamide and cyproterone acetate were studied both in vivo and in vitro. METHODS Schistosoma mansoni-infected mice were treated orally with 50-400 mg/kg of the antiandrogens 3 and 7 weeks post-infection. In addition, three drug combinations of nilutamide and praziquantel (200/100, 100/100 and 1...
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