A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...

      Addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and ATP depletion. At cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. Cytochrome P-450 inhibitors inhibited peroxynitrite formation and prev...

The identification of the efficiency of some mtDNA genes of Mus musculus species complex (house mouse) for biosystematics research was studied in this approach. Recent studies have made use of different mitochondrial genes including NADH dehydrogenase genes, cytochrome b gene, cytochrome oxidase genes, D-loop region and whole mtDNA genome to study the house mouse species. Usage of each of these...

the identification of the efficiency of some mtdna genes of mus musculus species complex (house mouse) for biosystematics research was studied in this approach. recent studies have made use of different mitochondrial genes including nadh dehydrogenase genes, cytochrome b gene, cytochrome oxidase genes, d-loop region and whole mtdna genome to study the house mouse species. usage of each of these...

An important role in ensuring the functioning of respiratory chain belongs to cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome oxidase). The key components these enzymatic are heme-containing cytochromes, number depends on balance heme synthesis catabolism. δ-Aminolevulinate synthase catalyzes first step biosynthetic pathway, while oxygena...

Introduction: Oxidative stress can impair the antioxidant protective capacity of the body, which is associated with decreased capacity of the body's internal defense system. There are some evidences that training and pumpkin seed (PS) consumption by different mechanisms have a protective effect on myocardial tissue by inhibiting oxidative stress. The aim of the present study was to investigate ...

in this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. diclofenac liver cytotoxicity was associated with reactive oxygen species (ros) formation and lipid peroxidation which were inhibited by antioxidants and ros scavengers, fer...

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sergentomyia sintoni is the natural vector of sauroleishmania species of lizards. this sandfly isabundance in and around the burrows of great gerbils. s. sintoni was collected from peridomestic animalshelters, inside and around houses and also from the nearby burrows of the gerbil reservoir hosts,rhombomys opimus, in several provinces of iran. mitochondrial cytochrome b (cyt b) of sandflies, wh...