According to the World Health Organization (WHO) 2016 classification, acute promyelocytic leukemia (APL) is placed in category of AML with recurrent cytogenetic abnormalities. Cytogenetic confirmation reciprocal translocation t(15:17) essential criteria for diagnosis this entity. However, these tests may have a significant time delay and it usually characteristic morphology abnormal promyelocyt...

The interpretation of cytogenetic abnormalities in multiple myeloma (MM) is often a challenging task. MM is characterized by several cytogenetic abnormalities that occur at various time points in the disease course. The interpretation of cytogenetic results in MM is complicated by the number and complexity of the abnormalities, the methods used to detect them and the disease stage at which they...

background: in algeria, the data on infertility and its various causes are rare. recently, the introduction of assisted reproduction has allowed expecting that 300000 couples, which represent 7% of couples of reproductive age, face difficulty conceiving a child. knowing that most idiopathic cases are likely to be due to chromosomal abnormalities, we aimed to investigate genetic defects by karyo...

tea (camellia sinensis) is one of the most economically important crops and is considered tobe the national drink of iran. although there has been an intensive cytogenetic study of tea in differentregions of the world, there has been no report from iran. therefore, the present investigation was carriedout in order to present the basic cytogenetical features of various tea cultivators grown in t...

INTRODUCTION Imatinib mesylate, a selective Bcr-Abl tyrosine kinase inhibitor, has proved to be most effective therapy of Philadelphia chromosome-positive chronic myelogenous leukemia. Imatinib induces complete haematological and cytogenetic response in high percentage of patients. OBJECTIVE The aim of this study was to identify potential prognostic factors before beginning treatment with ima...

Biological techniques such as Array-Comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH) and affymetrix single nucleotide pleomorphism (SNP) array have been used to detect cytogenetic aberrations. However, on genomic scale, these techniques are labor intensive and time consuming. Comparative genomic microarray analysis (CGMA) has been used to identify cytogenetic ch...

BACKGROUND Conventional karyotype has an established role in myelodysplastic syndrome (MDS) and is included in the International Prognostic Scoring System (IPSS) for patient risk stratification and treatment selection. Although some chromosomal abnormalities have been well characterized, the significance of several miscellaneous, infrequent, single chromosomal abnormalities remains to be define...

introduction: infertility is a significant multifactorial disorder that can be caused by chromosomal abnormalities. in this study, we aimed to cytogenetically investigate male and female patients admitted to the genetic diagnostic laboratory of kayseri educational hospital in kayseri, turkey with varied clinical prediagnoses of infertility. materials and methods: chromosomes from cultured perip...