background: correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. there are also reports about the role of cytokines and tumor necrosis factors-alpha (tnf-α) on corneal transplant in animal models. further studies are needed to clarify the role of cytokines in corneal allograft rejection...

background: pulmonary tuberculosis (ptb) has recently become a major problem in developed countries especially in immune compromised hiv infected individuals. cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   material & methods: in the present study the genotype frequencies of a number of polymorphic genes co...

Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the susceptibility to H. pylori or the disease outcomes. But the details and association to different polymorphis...

Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...

ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The a...

bronchial asthma is a multifactorial disease whereby both environmental and genetic factors contribute to its aetiology and/or clinical severity. the aim of this study was to examine the association of 22 cytokine gene polymorphism in the macedonian population with bronchial asthma (ba). the sample of the population comprised of 301 normal unrelated individuals and 74 patients with ba. cytokine...