There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

compounds containing triazene ring structure are cytotoxic agents and clinically used as antitumor alkylating agents. in this study, a series of triazene derivatives holding alkyl and aryl moieties were synthesized and proved to be potent cytotoxic agents in-vitro particularly against eight cancer cell lines (pc3, ht29, hela, hl60, jurkat, k562, mcf7, hepg2) and a non-cancerous cell line (huvec...

background and objectives: ziziphora clinopodioides is a perennial herb and grows widely in west and northwest of iran. the aerial parts are used as appetizer, carminative and antiseptic as well as for the treatment of medical conditions such as high blood pressure, asthma hyperhidrosis, palpitation and insomnia methods: the aerial parts of ziziphora clinopodioides lam. were extracted by ethano...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

DNA intercalators belong to aromatic heterocyclic compounds interacting reversibly with DNA. These compounds have been used extremely as cytotoxic agents against cancer. In this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. Twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

it has been reported that different species of euphorbia (euphorbiaceae) have antitumor activity. some reports also show that these plants have potential cytotoxic effect against different cell lines. in a program to screen the cytotoxicity of iranian native plants, euphorbia macroclada boiss. was collected, identified, and the cytotoxic activity of dichloromethane, ethylacetate, methanol extra...

DNA intercalators belong to aromatic heterocyclic compounds interacting reversibly with DNA. These compounds have been used extremely as cytotoxic agents against cancer. In this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. Twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

the present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of phlomis kurdica. the antioxidant and anti-tyrosinase activity of meoh extract from p. kurdica (mpk) were examined by dpph radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. furthermore, the effect of mpk on the melanin content, cellular tyrosinase ...

methanolic extract of 15 iranian medicinal plants were prepared and tested for their cytotoxic activities against three cancer cell lines (mcf7, hepg2 , wehi164) and one normal cell line (mdbk). some plants showed cytotoxic activities. the extract of ferula szowitsiana root, which proved to be the most active, was chosen for further phytochemical studies. the major compounds of the most potent ...

the current study was assigned to evaluate the total phenol, total flavonoid content (tpc, tfc) and antioxidant properties of extracts from the aerial parts of scrophularia frigida (s. frigida). extracts were also tested by preliminary phytochemical screening as well as cytotoxic activity against artemia salina, mcf-7 (human breast carcinoma) and sw-480 (colon carcinoma) and l-929 (normal) cell...