Glucocorticoids (GCs) are commonly co-administered with cisplatin in the treatment of patients with carcinomas to prevent drug-induced allergic reaction, nausea and vomiting. Although GC receptor (GR) is ubiquitous in carcinoma cells and has been linked to signal transduction pathways pertinent to cell growth and apoptosis, little is known regarding the possible effect of GC on the chemosensiti...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

Inhibition of tumor growth in a murine transplantable model of bladder cancer was attempted through manipulation of im mune response mechanisms by treatment of experimental an imals with indomethacm, a prostaglandin synthetase inhibitor, and/or polyinosinic:polycytidylic acid [poly(l:Q], an inducer of Interferon. Tumor-bearing animals and age-matched controls were inoculated i.p. with either ph...

The effect of the antineoplastic agent cis-diamminedichloroplatinum(II) (cis-DDP) on spontaneous cytotoxicity of human mononuclear cells in vitro was assessed. cis-DDP enhanced spontaneous monocyte-mediated cytotoxicity 300% compared to control values. Further, this spontaneous monocyte killing developed earlier (3 to 4 days) than did that of untreated cells (5 to 7 days). Since monocyte cytoto...

the biological application of nanoparticles (nps) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. the cytotoxicity was evaluated by mtt and ldh assays. the apoptotic effect of free icd-85 and icd-85 nps on hela cells was assessed using caspase-8 colorimetric assay. the mtt assay showed that icd-85 nps could enhance the in-vitro cyt...

Objective(s): Exosomes are endogenous nanovesicles act as intercellular communication tools which have been considered to utilize as drug delivery systems. As transporting therapeutic molecules into brain has obstacles, preparing exosomes which have the potential to pass through its barriers is great challenge. Methods: Exosomes isolated from cell culture media of U87 glioblastoma ...

The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitum...