The chemoresistance of non-small cell lung cancer (NSCLC) that occurs in docetaxel (DOC) chemotherapy substantially decreases the survival of patients. To overcome DOC-induced chemoresistance, we established DOC-selected A549 lung cancer sublines (A549/D16 and A549/D32) and revealed that both sublines were cross-resistant to vincristine (VCR) and doxorubicin (DXR). Notably, both sublines were m...

The rapidly growing problem of increased resistance to classical antibiotics makes the development of new classes of antimicrobial agents with lower rates of resistance urgent. Amphipathic cationic α-helical antimicrobial peptides have been proposed as a potential new class of antimicrobial agents. The goal of this study was to take a broad-spectrum, 26-residue, antimicrobial peptide in the all...

Organized uterine contractions, including those necessary for parturition, are dependent on calcium entry through voltage-gated calcium channels in myometrial smooth muscle cells. Recent evidence suggests that small-conductance Ca(2+)-activated potassium channels (K(Ca)2), specifically isoforms K(Ca)2.2 and 2.3, may control these contractions through negative feedback regulation of Ca(2+) entry...

Presented a method for quantizing the wideband line spectrum frequencies (LSF) with a specific class of near-ellipsoidal lattice codes referred to as “generalized Voronoi codes”. Optimization procedures are described with respect to a weighted mean-square error (WMSE). The lattices D16, RE16 or R 16 are applied to quantize the LSF with no frequency splitting. Results indicate that near-ellipsoi...

OBJECTIVE To determine whether serum hyperglycosylated human chorionic gonadotropin (hhCG) measured as early as 9 days after egg retrieval can predict ongoing pregnancies after in vitro fertilization and fresh embryo transfer (IVF-ET). DESIGN Cohort SETTING Academic assisted reproduction center. PATIENT(S) Consecutive patients undergoing IVF-ET INTERVENTION(S): Serum hhCG and hCG levels m...

This deliverable presents several methodologies and preliminary experimental results regarding the design of low-power memory subsystems. The existing literature is first reviewed in order to identify the class of memory design approaches that are most suitable to the EASY project, namely, those which are applicable in the context of the HIPERLAN/2 SoC development and, at the same time, are gen...