Dopamine D2 receptor interactions with arrestins and arrestin-dependent internalization have been characterized using heterologously expressed D2 receptor and arrestins. The purpose of this study was to investigate D2 receptor interaction with endogenous arrestins. Arrestin2 and arrestin3 in striatal homogenates bound to the third cytoplasmic loop of the D2 receptor, and purified arrestin2 and ...

In this paper, I present the modal adaptive logic AJ (based on S5) as well as the discussive logic D2 that is defined from it. D2 is the adaptive version of Jaśkowski’s paraconsistent system D2. Like D2, D2 validates all single-premise rules of Classical Logic. However, for formulas that behave consistently, D2 moreover validates all multiple-premise rules of Classical Logic. D2 thus leads to a...

2.1 The Case All di 6= 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.2 The Case d0 = 0 < d1 ≤ d2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.3 The Case d0 < 0 = d1 < d2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.4 The Case d0 ≤ d1 < d2 = 0 . . . . . . . . . . . . . . . . . . . . . . . ...

Aberrant regulation of transition metals and the resultant disregulation of neuronal reactive oxygen species (ROS) are considered significant in the etiology of Alzheimer's disease (AD). We determined the solution structure of the D2 domain of APL-1 (APL1-D2), the Caenorhabditis elegans ortholog of the amyloid precursor protein domain 2 (APP-D2). The copper binding affinities of APL1-D2 and APP...

Chimeric D1/D2 receptors were constructed to identify structural determinants of drug affinity and efficacy. We previously reported that chimeras that had D1 receptor transmembrane domain VII together with amino-terminal sequence from the D2 receptor were nonfunctional. D2/D1 chimeras were constructed that contained D2 receptor sequence at the amino- and carboxyl-terminal ends and D1 receptor s...

A macroscopic approximation of RNA secondary structure (Vialette, CPM 2002): • a subsequence of consecutive bases → an interval • a stacked pairing of two disjoint subsequences → a 2interval Three Binary Relations For two 2-intervals D1 = (I1, J1) and D2 = (I2, J2), D1 and D2 are disjoint if the four intervals I1, J1, I2, and J2 are pairwise disjoint. Preceding: D1 < D2 ⇐⇒ I1 < J1 < I2 < J2. Ne...

previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. both ascorbic acid and dopamine receptor have an important role in learning and memory processes. however, the central interaction between ascorbic acid and dopamine d2 receptor on spatial learning and memory has not yet been elucidated. all experiments were carried out on mal...

Linear complementary dual (LCD) codes are linear that intersect with their trivially. We study the largest minimum weight d2(n,k) among all binary LCD [n,k] and d3(n,k) ternary codes. The weights d2(n,5) d3(n,4) partially determined. also determine d2(n,n−5), d3(n,n−i) for i∈{2,3,4}, n∈{11,12,…,19}.