The objectives of this study were: 1) to examine effects of a dietary sodium bentonite, ASTRABEN–20 (AB20) [Prince Agri Products, Inc., Quincy, Ill.], on in vitro binding of T2 toxin and aflatoxin B (AFB1); ® 1 and 2) to examine the effects of AB20 in broiler chicks fed 6 ppm dietary T2 toxin (T2) or 4 ppm aflatoxin B1 (AFB1) to 21 d. Day-old male broiler chicks were randomly placed in batterie...

Responses of autotrophic and heterotrophic processes to nutrients and trace elements were examined in a series of experimental estuarine food webs of increasing trophic complexity using twenty 1-m3 mesocosms. Nutrients (nitrogen and phosphorus) and trace elements (a mix of arsenic, copper, cadmium) were added alone and in combination during four experimental runs spanning from spring 1997 to sp...

BACKGROUND Intrauterine growth restriction (IUGR) is thought to lead to fetal programming that in turn contributes to developmental changes of many organs postnatally. There is evidence that IUGR is a risk factor for the development of metabolic and cardiovascular disease later in life. A higher incidence of breast cancer was also observed after IUGR. This could be due to changes in mammary gla...

There are few studies describing the extent to which low iron status affects osteoblastogenesis, despite evidence that iron deficiency produces adverse effects on bone density. The purpose of this study was to evaluate alterations in intracellular iron status by measuring iron-regulated gene and protein expression and to describe development of osteoblast phenotype in primary cells treated with...

Background: The composition of dietary fatty acids (FA) during early life may impact adult adipose tissue (AT) development. We investigated the effects of a-linolenic acid (ALA) intake during the suckling/weaning period on AT development and metabolic markers in the guinea pig (GP). Methods: Newborn GP were fed a 27%-fat diet (w/w %) with high (10%-ALA group), moderate (2.4%-ALA group) or low (...

OBJECTIVES The aim of this study was to assess growth and nutritional biomarkers of preterm infants fed human milk (HM) supplemented with a new powdered HM fortifier (nHMF) or a control HM fortifier (cHMF). The nHMF provides similar energy content, 16% more protein (partially hydrolyzed whey), and higher micronutrient levels than the cHMF, along with medium-chain triglycerides and docosahexaeno...

Background: Currently available preterm formulas with energy contents of 3350 kJ (800 kcal)/L promote weight and length gain at rates at or above intrauterine growth rates but disproportionately increase total body fat. Objective: The objective of this study was to determine whether fat accretion in formula-fed, very-low-birth-weight (VLBW) infants could be decreased and net protein gain mainta...

BACKGROUND Standardized patient-reported outcome (PRO) questionnaires can be utilized to evaluate treatment satisfaction (subjective evaluation of treatment) in patients with type 2 diabetes (T2D). These outcomes are important because they may affect patient adherence and overall study results. METHODS PROs were evaluated in two randomized 26-week clinical trials in Japanese patients with T2D...

In the adult rat, there is a general correspondence between the sizes of motoneurons, motor units, and muscle fibers that has particular functional importance in motor control. During early postnatal development, after the establishment of singular innervation, there is rapid growth of diaphragm muscle (Dia(m)) fibers. In the present study, the association between Dia(m) fiber growth and change...