To characterize the influences of leukotriene D4 on regional vascular smooth muscle, effects of leukotriene D4 on vasomotor tone of canine renal and superior mesenteric arterial rings were determined. Vascular smooth muscle tone was measured with isometric force transducers. After tone had been induced with norepinephrine, leukotriene D4, in concentrations of 10(-8) M to 10(-7) M, produced dose...

Interrupting the hormonal balance of an organism by interfering with hormones and their target receptors gives rise to various problems such as developmental disorders. Collectively, these reagents are known as endocrine disruptors (EDs). Cyclic volatile methyl siloxanes (cVMSs) are a group of silicone polymers that including octamethylcyclotetrasiloxane (D4). In the present study, we examined ...

For the large and chemically diverse GMTKN55 benchmark suite, we have studied performance of density-corrected density functional theory (HF-DFT), compared to self-consistent DFT, for several pure hybrid GGA meta-GGA exchange-correlation (XC) functionals (PBE, BLYP, TPSS, SCAN) as a function percentage HF exchange in hybrid. The D4 empirical dispersion correction has been added throughout. subs...

This paper proposes D4 FLMS-GSC algorithm interpreted as Daubechies D4 wavelet filter instead of subtractor filter which processes array antenna output. The structure of the proposed D4 FLMS-GSC algorithm has characteristic of reducing the computational requirement one-half compared to the FLMS-GSC algorithm. In addition, we obtain the MSE characteristics and adaptive beampattern of the D4 FLMS...

We study a configuration in matrix theory carying longitudinal fivebrane charge, i.e. a D0-D4 bound state. We calculate the one-loop effective potential between a D0-D4 bound state and a D0–anti-D4 bound state and compare our results to a supergravity calculation. Next, we identify the tachyonic fluctuations in the D0-D4 and D0–anti-D4 system. We analyse classically the action for these tachyon...

Dopaminergic neurotransmission in the prefrontal cortex (PFC) plays an important role in regulating cognitive processes and emotional status. The dopamine D4 receptor, which is highly enriched in the PFC, is one of the principal targets of antipsychotic drugs. To understand the cellular mechanisms and functional implications of D4 receptors, we examined the impact of D4 receptors in PFC pyramid...

D4-GDI is a key regulator of Rho GTPases that have been implicated in several aspects of breast tumorigenesis. We have previously found that D4-GDI was selectively expressed in breast cancer cell lines over normal mammary epithelial cells [45]. In this study, we investigated the expression level of D4-GDI in breast tumor specimens (n = 165) by immunohistochemistry using a validated antibody tha...

In the November 2001 issue of EHP, Luu and Hutter (1) described a physiologically based pharmacokinetic (PBPK) model for the bioavailability of octamethylcyclotetrasiloxane (D4) following exposure to D4 by inhalation and implantation. In this paper the authors developed a PBPK model that used a very limited data set obtained after either single or repeated intravenous (iv) administration of D4 ...

Vascular smooth muscle cells (VSMCs) proliferation and migration, which are central in the development of vascular diseases, are regulated by numerous hormones and humoral factors. Activation of the insulin receptor stimulates VSMCs proliferation while dopamine receptors, via D1 and D3 receptors, inhibit the stimulatory effects of norepinephrine on VSMCs proliferation. We hypothesize that activ...