نتایج جستجو برای: dasatinib

تعداد نتایج: 1954  

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016
Jorge E Cortes Giuseppe Saglio Hagop M Kantarjian Michele Baccarani Jiří Mayer Concepción Boqué Neil P Shah Charles Chuah Luis Casanova Brigid Bradley-Garelik George Manos Andreas Hochhaus

PURPOSE We report the 5-year analysis from the phase III Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients (DASISION) trial, evaluating long-term efficacy and safety outcomes of patients with chronic myeloid leukemia (CML) in chronic phase (CP) treated with dasatinib or imatinib. PATIENTS AND METHODS Patients with newly diagnosed CML-CP were randomly assigne...

2015
Naif I. AlJohani Simon Carette Jeffrey H. Lipton

INTRODUCTION Chronic myelogenous leukemia is often treated using tyrosine kinase inhibitors such as dasatinib. Here we describe a rare case of inflammatory myopathy in a patient with chronic myelogenous leukemia treated with the tyrosine kinase inhibitor dasatinib. CASE PRESENTATION A 69-year-old Caucasian man with imatinib-resistant chronic myelogenous leukemia achieved complete molecular re...

2015
Xiaochun Yang Jincheng Wang Jiabin Dai Jinjin Shao Jian Ma Chao Chen Shenglin Ma Qiaojun He Peihua Luo Bo Yang

Liver dysfunction is a common side effect associated with the treatment of dasatinib and its mechanism is poorly understood. Autophagy has been thought to be a potent survival or death factor for liver dysfunction, which may shed the light on a novel strategy for the intervention of hepatotoxicity caused by dasatinib. In this study, we show for the first time that autophagy is induced, which is...

2017
Swapan K Dasgupta Anhquyen Le K Vinod Vijayan Perumal Thiagarajan

Treatment with dasatinib, a tyrosine kinase inhibitor, is associated with edema, pleural effusion, and pulmonary edema. We investigated the effect of dasatinib on the barrier function of human microvascular endothelial cells-1 (HMEC-1) in vitro and in vivo. The permeability of HMEC-1 to fluorescein isothiocyante (FITC)-dextran increased in Transwell chambers within 5 min following the addition ...

Journal: :Clinical lymphoma, myeloma & leukemia 2015
Ceyda Tunakan Dalgıç Burçin Tezcanlı Kaymaz Melda Cömert Özkan Ayşegül Dalmızrak Fahri Şahin Güray Saydam

We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significan...

2014
Alex J. Eustace Susan Kennedy Anne-Marie Larkin Thamir Mahgoub Dimitrios Tryfonopoulos Lorraine O'Driscoll Martin Clynes John Crown Norma O'Donovan

Dasatinib has anti-proliferative and anti-invasive effects in melanoma cell lines. However clinical trials have shown modest activity for dasatinib in metastatic melanoma. Although dasatinib targets SRC kinase, neither expression nor phosphorylation of SRC appears to predict response to dasatinib. Identification of predictive biomarkers for dasatinib may facilitate selection of melanoma patient...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Robert C Bauer Jana Sänger Christian Peschel Justus Duyster Nikolas von Bubnoff

PURPOSE Dasatinib and nilotinib are active in imatinib-resistant chronic myelocytic leukemia (CML) and many patients undergo sequential treatment. We aimed at modeling sequential tyrosine kinase inhibitor (TKI) resistance in vitro to compare the sequences imatinib-nilotinib-dasatinib and imatinib-dasatinib-nilotinib. EXPERIMENTAL DESIGN We designed an in vitro model for sequential TKI resista...

Journal: :Cancer immunology research 2017
Can Hekim Mette Ilander Jun Yan Erin Michaud Richard Smykla Markus Vähä-Koskela Paula Savola Siri Tähtinen Leena Saikko Akseli Hemminki Panu E Kovanen Kimmo Porkka Francis Y F Lee Satu Mustjoki

Dasatinib, a broad-range tyrosine kinase inhibitor, induces rapid mobilization of lymphocytes and clonal expansion of cytotoxic cells in leukemia patients. Here, we investigated whether dasatinib could induce beneficial immunomodulatory effects in solid tumor models. The effects on tumor growth and on the immune system were studied in four different syngeneic mouse models (B16.OVA melanoma, 195...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Jie Huang Wei Hu Justin Bottsford-Miller Tao Liu Hee Dong Han Behrouz Zand Sunila Pradeep Ju-Won Roh Duangmani Thanapprapasr Heather J Dalton Chad V Pecot Rajesh Rupaimoole Chunhua Lu Bryan Fellman Diana Urbauer Yu Kang Nicholas B Jennings Li Huang Michael T Deavers Russell Broaddus Robert L Coleman Anil K Sood

PURPOSE EphA2 is an attractive therapeutic target because of its diverse roles in cancer growth and progression. Dasatinib is a multikinase inhibitor that targets EphA2 and other kinases. However, reliable predictive markers and a better understanding of the mechanisms of response to this agent are needed. EXPERIMENTAL DESIGN The effects of dasatinib on human uterine cancer cell lines were ex...

Journal: :Blood 2012
Hagop M Kantarjian Neil P Shah Jorge E Cortes Michele Baccarani Mohan B Agarwal María Soledad Undurraga Jianxiang Wang Juan Julio Kassack Ipiña Dong-Wook Kim Michinori Ogura Carolina Pavlovsky Christian Junghanss Jorge H Milone Franck E Nicolini Tadeusz Robak Jan Van Droogenbroeck Edo Vellenga M Brigid Bradley-Garelik Chao Zhu Andreas Hochhaus

Dasatinib is a highly potent BCR-ABL inhibitor with established efficacy and safety in imatinib-resistant/-intolerant patients with chronic myeloid leukemia (CML). In the phase 3 DASISION trial, patients with newly diagnosed chronic-phase (CP) CML were randomized to receive dasatinib 100 mg (n = 259) or imatinib 400 mg (n = 260) once daily. Primary data showed superior efficacy for dasatinib co...

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